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Isorugulosuvine

Family: Fungi - Trichocomaceae
Kingdom: Fungi
Class: Alkaloid
- Subclass: Diketopiperazine

Canonical Smiles	O=C1N[C@@H](Cc2ccccc2)C(=O)N[C@H]1Cc1c[nH]c2c1cccc2
InChI	InChI=1S/C20H19N3O2/c24-19-17(10-13-6-2-1-3-7-13)22-20(25)18(23-19)11-14-12-21-16-9-5-4-8-15(14)16/h1-9,12,17-18,21H,10-11H2,(H,22,25)(H,23,24)/t17-,18-/m0/s1
InChIKey	CUVKAUWOMPJEMI-ROUUACIJSA-N
Formula	C₂₀H₁₉N₃O₂
HBA	2
HBD	3
MW	333.39
Rotatable Bonds	4
TPSA	73.99
LogP	1.94
Number Rings	4
Number Aromatic Rings	3
Heavy Atom Count	25
Formal Charge	0
Fraction CSP3	0.2
Exact Mass	333.15
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Emericella dentata	Trichocomaceae	Fungi	286160

Showing of synonyms

Hamed A, Abdel-Razek A.S, et al. (2021). Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies. Nat Prod Res,2021,35(21),3830-3838. [View] [PubMed]

Pubchem: 7408486

Cas: 6521-48-8

Zinc: ZINC000004899716

Chebi: 68230

Nmrshiftdb2: 60147089

Metabolights: MTBLC68230

Chembl: CHEMBL190059

No compound-protein relationship available.

SMILES: c1cccc(c12)[nH]cc2CC(C3=O)NC(=O)C(N3)Cc4ccccc4

Level: 2

Mol. Weight: 333.39 g/mol

SMILES: N1CC(=O)NC(C1=O)Cc2c[nH]c(c23)cccc3

Level: 1

Mol. Weight: 333.39 g/mol

SMILES: N1CC(=O)NC(C1=O)Cc2ccccc2

Level: 1

Mol. Weight: 333.39 g/mol

SMILES: c1c[nH]c(c12)cccc2

Level: 0

Mol. Weight: 333.39 g/mol

SMILES: O=C1CNC(=O)CN1

Level: 0

Mol. Weight: 333.39 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 333.39 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -5.22
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.65
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.54

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.9
Plasma Protein Binding: 81.23
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 8.88
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: -0.04
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.45
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 4.45
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -4.83
Rat (Acute): 2.34
Rat (Chronic Oral): 2.43
Fathead Minnow: 4.02
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 473.12
Hydration Free Energy: -11.1
Log(D) at pH=7.4: 2.9
Log(P): 1.92
Log S: -4.15
Log(Vapor Pressure): -10.13
Melting Point: 240.92
pKa Acid: 9.08
pKa Basic: 5.69

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.9639
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.9623
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.9484
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.9409
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.9388
Aklanonic acid methyl ester cyclase AcmA	O52646	DNRD_STRGJ	Streptomyces galilaeus	3	0.9339
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.9319
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9315
Ribosomal protein S6 kinase beta-1	P23443	KS6B1_HUMAN	Homo sapiens	3	0.9310
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9289
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9281
Ribosomal protein S6 kinase beta-1	P23443	KS6B1_HUMAN	Homo sapiens	3	0.9241
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.9228
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	3	0.9221
Cytochrome P450 2C19	P33261	CP2CJ_HUMAN	Homo sapiens	3	0.9193
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.9187
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.9179
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.9169
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.9156
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.9130
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	3	0.9130
Ribosomal protein S6 kinase beta-1	P23443	KS6B1_HUMAN	Homo sapiens	3	0.9128
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9107
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.9086
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9031
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.9026
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.9019
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.9010
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8985
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8949
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	3	0.8949
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8938
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8908
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8883
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8850
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.8837
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	3	0.8830
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.8783
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8772
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8755
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8744
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8738
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.8724
Chloramphenicol acetyltransferase	P62577	CAT_ECOLX	Escherichia coli	3	0.8709
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.8703
Abscisic acid receptor PYL1	Q8VZS8	PYL1_ARATH	Arabidopsis thaliana	3	0.8703
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8698
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8684
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.8658
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8638
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8610
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	3	0.8584
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8581
glutaryl-CoA dehydrogenase (ETF)	Q3JP94	Q3JP94_BURP1	Burkholderia pseudomallei	3	0.8564
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8552
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8543
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8538
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.8537
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.8511
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.8510
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8503
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	3	0.8503
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8494
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8479
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.8463
Bromodomain testis-specific protein	Q58F21	BRDT_HUMAN	Homo sapiens	3	0.8446
Gag-Pol polyprotein	P0C6F2	POL_HV1LW	Human immunodeficiency virus type 1 group M subtype B	3	0.8432
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8431
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8429
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.8417
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.8411
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8411
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.8407
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8397
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8378
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	3	0.8329
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.8322
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.8320
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8319
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.8318
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.8307
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8278
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.8253
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8253
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.8222
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8207
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.8202
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.8186
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8185
Genome polyprotein	P03303	POLG_HRV14	Human rhinovirus 14	3	0.8170
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.8156
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.8141
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	3	0.8141
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.8136
Protein S100-A4	P26447	S10A4_HUMAN	Homo sapiens	3	0.8099
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8087
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8086
Methionine--tRNA ligase	P00959	SYM_ECOLI	Escherichia coli	3	0.8072
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8025
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8007
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.8003
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	4	0.7994
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7973
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7967
Pol protein	Q000H7	Q000H7_9HIV1	Human immunodeficiency virus 1	3	0.7959
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7924
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7916
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7915
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7910
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7863
Ribosomal protein S6 kinase beta-1	P23443	KS6B1_HUMAN	Homo sapiens	3	0.7863
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.7862
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7858
Protein mono-ADP-ribosyltransferase PARP15	Q460N3	PAR15_HUMAN	Homo sapiens	4	0.7856
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	3	0.7853
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	3	0.7851
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7848
Glycylpeptide N-tetradecanoyltransferase	Q4Q5S8	Q4Q5S8_LEIMA	Leishmania major	3	0.7843
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7841
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7834
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7832
Nociceptin receptor	P41146	OPRX_HUMAN	Homo sapiens	3	0.7829
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	3	0.7818
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	3	0.7815
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7805
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7797
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	2	0.7793
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7781
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	3	0.7778
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	3	0.7769
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7767
Serine/threonine-protein kinase VRK1	Q99986	VRK1_HUMAN	Homo sapiens	3	0.7764
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7753
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7735
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7734
Abscisic acid receptor PYL1	Q8VZS8	PYL1_ARATH	Arabidopsis thaliana	3	0.7733
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7723
Ribosomal protein S6 kinase beta-1	P23443	KS6B1_HUMAN	Homo sapiens	3	0.7718
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.7718
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7717
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7714
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	4	0.7706
Metallo-beta-lactamase type 2	P52699	BLAB_SERMA	Serratia marcescens	3	0.7703
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7698
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7692
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	3	0.7683
Sterol 14alpha-demethylase	P9WPP9	CP51_MYCTU	Mycobacterium tuberculosis	3	0.7677
Cholesterol 24-hydroxylase	Q9Y6A2	CP46A_HUMAN	Homo sapiens	3	0.7668
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7666
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7665
Abscisic acid receptor PYL3	Q9SSM7	PYL3_ARATH	Arabidopsis thaliana	2	0.7658
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7647
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	4	0.7637
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.7636
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7632
Calmodulin	P62157	CALM_BOVIN	Bos taurus	3	0.7618
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7612
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.7610
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7604
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7603
Endolysin	P00720	ENLYS_BPT4	Enterobacteria phage T4	3	0.7599
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7594
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7594
Abscisic acid receptor PYL3	Q9SSM7	PYL3_ARATH	Arabidopsis thaliana	3	0.7593
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7589
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7582
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7580
Putative snRNP Sm-like protein	Q8ZYG5	Q8ZYG5_PYRAE	Pyrobaculum aerophilum	2	0.7575
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7573
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7570
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7568
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7562
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7561
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7561
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7560
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7560
Orf1ab polyprotein	Q6T1E9	Q6T1E9_CVHSA	SARS coronavirus CUHK-L2	3	0.7554
Chymotrypsinogen A	P00766	CTRA_BOVIN	Bos taurus	3	0.7545
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7541
Bifunctional protein GlmU	P43889	GLMU_HAEIN	Haemophilus influenzae	3	0.7539
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.7531
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7526
RAC-alpha serine/threonine-protein kinase	P31749	AKT1_HUMAN	Homo sapiens	3	0.7523
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.7522
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	4	0.7511
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7506
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7498
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	2	0.7496
Aminopeptidase N	P04825	AMPN_ECOLI	Escherichia coli	3	0.7493
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7489
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7487
Beta-glucuronidase	P05804	BGLR_ECOLI	Escherichia coli	3	0.7487
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7487
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7485
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	2	0.7477
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7456
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7451
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7449
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7435
Prostaglandin E synthase 2	Q9N0A4	PGES2_MACFA	Macaca fascicularis	3	0.7430
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7428
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7426
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.7425
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7422
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	2	0.7420
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7417
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7412
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7411
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7407
Fatty acid-binding protein, adipocyte	P15090	FABP4_HUMAN	Homo sapiens	2	0.7403
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7401
Oxygen-insensitive NAD(P)H nitroreductase	P38489	NFSB_ECOLI	Escherichia coli	3	0.7398
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7395
N5-carboxyaminoimidazole ribonucleotide mutase	P0AG18	PURE_ECOLI	Escherichia coli	4	0.7393
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7385
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7381
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7375
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7368
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7367
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7366
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7362
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7362
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	4	0.7357
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7357
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	P80030	FABI_BRANA	Brassica napus	3	0.7351
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7347
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7345
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7344
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7334
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7333
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7330
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.7327
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7320
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7317
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7315
Heat shock 70 kDa protein 1B	P0DMV9	HS71B_HUMAN	Homo sapiens	3	0.7310
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7307
Serine protease 1	P00760	TRY1_BOVIN	Bos taurus	4	0.7306
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7306
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7305
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7302
C-C chemokine receptor type 5	P51681	CCR5_HUMAN	Homo sapiens	3	0.7298
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7298
Carbonic anhydrase 13	Q8N1Q1	CAH13_HUMAN	Homo sapiens	3	0.7294
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7294
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	2	0.7291
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	2	0.7289
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7278
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7277
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	3	0.7277
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.7268
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	4	0.7268
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	2	0.7262
Annexin A5	P08758	ANXA5_HUMAN	Homo sapiens	2	0.7261
Rho-associated protein kinase 1	Q13464	ROCK1_HUMAN	Homo sapiens	3	0.7260
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7257
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7255
Tryptase alpha/beta-1	Q15661	TRYB1_HUMAN	Homo sapiens	3	0.7254
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7254
Cytochrome P450 2C9	P11712	CP2C9_HUMAN	Homo sapiens	2	0.7250
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.7248
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7246
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7241
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	2	0.7240
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7239
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7239
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7236
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	2	0.7235
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7234
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7226
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7225
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7224
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7221
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7212
Myotonin-protein kinase	Q09013	DMPK_HUMAN	Homo sapiens	3	0.7212
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	2	0.7209
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7205
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	2	0.7204
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7203
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7203
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7202
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7201
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7200
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7200
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7200
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7195
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	3	0.7189
NAD(P) transhydrogenase subunit alpha part 1	Q2RSB2	PNTAA_RHORT	Rhodospirillum rubrum	3	0.7188
Caffeoyl-CoA O-methyltransferase	Q40313	CAMT_MEDSA	Medicago sativa	3	0.7187
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7186
Transthyretin	Q9PTT3	Q9PTT3_SPAAU	Sparus aurata	3	0.7183
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7182
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	2	0.7180
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7177
Penicillin V acylase	P12256	PAC_LYSSH	Lysinibacillus sphaericus	3	0.7177
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7171
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	2	0.7170
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	2	0.7167
11-beta-hydroxysteroid dehydrogenase 1	Q6QLL4	DHI1_CAVPO	Cavia porcellus	3	0.7161
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7159
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	2	0.7159
Glutaminyl-peptide cyclotransferase	Q16769	QPCT_HUMAN	Homo sapiens	3	0.7158
4-chlorobenzoyl CoA ligase	Q8GN86	Q8GN86_9BURK	Alcaligenes sp. AL3007	2	0.7158
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7155
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7154
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	2	0.7154
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7150
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7145
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7144
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7142
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7140
RAC-alpha serine/threonine-protein kinase	P31749	AKT1_HUMAN	Homo sapiens	3	0.7135
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	2	0.7134
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7134
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7133
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7122
Ribosomal protein S6 kinase beta-1	P23443	KS6B1_HUMAN	Homo sapiens	2	0.7121
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7120
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7119
Dihydroorotate dehydrogenase (quinone), mitochondrial	Q63707	PYRD_RAT	Rattus norvegicus	3	0.7119
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7118
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7110
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7109
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7107
7,8-dihydroneopterin aldolase	J7VEZ6	J7VEZ6_BACCE	Bacillus cereus BAG3X2-1	3	0.7106
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7105
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7104
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7103
Orf1a polyprotein	Q692E5	Q692E5_CVHSA	SARS coronavirus TJF	2	0.7098
Cytochrome P450 2C5	P00179	CP2C5_RABIT	Oryctolagus cuniculus	3	0.7096
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7096
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	3	0.7096
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.7095
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7087
4-chlorobenzoyl CoA ligase	Q8GN86	Q8GN86_9BURK	Alcaligenes sp. AL3007	2	0.7086
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7082
Cystathionine beta-lyase MetC	P06721	METC_ECOLI	Escherichia coli	3	0.7082
Acidic phospholipase A2 3	P60045	PA2A3_NAJSG	Naja sagittifera	2	0.7079
Kynurenine 3-monooxygenase	P38169	KMO_YEAST	Saccharomyces cerevisiae	2	0.7078
Virulence sensor histidine kinase PhoQ	P0DM80	PHOQ_SALTY	Salmonella typhimurium	3	0.7077
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7076
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7075
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7073
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7072
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	2	0.7072
11-beta-hydroxysteroid dehydrogenase 1	P50172	DHI1_MOUSE	Mus musculus	3	0.7070
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7068
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7064
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7063
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	2	0.7062
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7058
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7056
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7055
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	2	0.7053
AGAP003309-PA	A0A1U7F4W2	A0A1U7F4W2_ANOGA	Anopheles gambiae	3	0.7048
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7042
Muconolactone Delta-isomerase	Q8G9L0	Q8G9L0_RHOOP	Rhodococcus opacus	2	0.7038
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7036
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	2	0.7035
Fatty acid-binding protein, intestinal	P12104	FABPI_HUMAN	Homo sapiens	3	0.7028
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7027
Phenylpyruvate C(3)-methyltransferase	Q643C8	MPPJ_STRHY	Streptomyces hygroscopicus	2	0.7023
Cytochrome P450 3A4	P08684	CP3A4_HUMAN	Homo sapiens	3	0.7014
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7011
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7008
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7005
Unconventional myosin-Va	Q02440	MYO5A_CHICK	Gallus gallus	2	0.7002

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