Buddlenol D - Compound Card

Buddlenol D

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Buddlenol D

Structure
Zoomed Structure
  • Family: Umbelliferae
  • Kingdom: Plantae
  • Class: Lignan
Canonical Smiles COc1cc(cc(c1O[C@H]([C@@H](c1cc(OC)c(c(c1)OC)O)O)CO)OC)C1OC[C@H]2[C@@H]1CO[C@@H]2c1cc(OC)c(c(c1)OC)O
InChI InChI=1S/C33H40O13/c1-38-21-7-16(8-22(39-2)29(21)36)28(35)27(13-34)46-33-25(42-5)11-18(12-26(33)43-6)32-20-15-44-31(19(20)14-45-32)17-9-23(40-3)30(37)24(10-17)41-4/h7-12,19-20,27-28,31-32,34-37H,13-15H2,1-6H3/t19-,20-,27-,28+,31+,32?/m0/s1
InChIKey CQPUHIMEOUJAQQ-LILUDEBISA-N
Formula C33H40O13
HBA 13
HBD 4
MW 644.67
Rotatable Bonds 13
TPSA 163.99
LogP 3.7
Number Rings 5
Number Aromatic Rings 3
Heavy Atom Count 46
Formal Charge 0
Fraction CSP3 0.45
Exact Mass 644.25
Number of Lipinski Rule Violations 2
# Species Family Kingdom NCBI Taxonomy ID
1 Eryngium triquetrum Umbelliferae Plantae 1094608

Showing of synonyms

  • Bouzergoune F, Ciavatta M.L, et al. (2016). Phytochemical Study of Eryngium triquetrum: Isolation of Polyacetylenes and Lignans. Planta Med,2016,82(16),1438-1445. [View] [PubMed]
Pubchem: 157010307

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CCOc(cc2)ccc2C3OCC(C34)C(OC4)c5ccccc5

Level: 3

Mol. Weight: 386.49 g/mol

Structure

SMILES: c1ccccc1CCOc(cc2)ccc2C3OCC(C34)COC4

Level: 2

Mol. Weight: 310.39 g/mol

Structure

SMILES: c1ccccc1C(OC2)C(C23)COC3c4ccccc4

Level: 2

Mol. Weight: 266.34 g/mol

Structure

SMILES: c1ccccc1CCOc2ccccc2

Level: 1

Mol. Weight: 198.27 g/mol

Structure

SMILES: C1OCC(C12)COC2c3ccccc3

Level: 1

Mol. Weight: 190.24 g/mol

Structure

SMILES: C1OCC(C12)COC2

Level: 0

Mol. Weight: 114.14 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.62
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.690
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
65.54

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.800
Plasma Protein Binding
69.52
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
12.510
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.710
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.350
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
8.300
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-121195.860
Rat (Acute)
2.460
Rat (Chronic Oral)
3.450
Fathead Minnow
166.920
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Toxic

General Properties

Boiling Point
8525.400
Hydration Free Energy
-2.920
Log(D) at pH=7.4
2.910
Log(P)
0.9
Log S
-4.9
Log(Vapor Pressure)
-299.48
Melting Point
187.96
pKa Acid
7.15
pKa Basic
0.61
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9296
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9290
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9266
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 4 0.9240
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9187
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9165
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.9060
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9009
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8887
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.8877
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8865
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8826
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8811
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.8805
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8747
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8737
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8697
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8659
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8621
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8613
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 4 0.8597
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8470
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8427
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8422
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8398
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8380
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8379
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8366
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8358
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8342
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 4 0.8328
Uracil-DNA glycosylase P20536 UNG_VACCC Vaccinia virus 4 0.8292
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8286
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.8285
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8280
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.8238
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8208
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8184
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8178
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8154
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8149
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8123
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8120
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8101
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8089
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8085
Uracil-DNA glycosylase P13051 UNG_HUMAN Homo sapiens 4 0.8081
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.8077
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8012
Thymidylate kinase Q9KQI2 KTHY_VIBCH Vibrio cholerae serotype O1 4 0.7995
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7969
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7967
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7964
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7960
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7939
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 4 0.7914
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7891
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7891
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7886
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7870
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7834
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7832
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7818
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7792
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7756
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7716
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7706
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7703
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7697
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7683
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7673
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7650
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7645
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 4 0.7620
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7618
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7605
Beta-glucosidase 1A Q25BW5 BGL1A_PHACH Phanerodontia chrysosporium 3 0.7598
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7564
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7559
Uracil-DNA glycosylase P9WFQ9 UNG_MYCTU Mycobacterium tuberculosis 4 0.7557
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7546
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7544
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7544
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7537
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7530
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7521
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7510
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7493
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7465
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7465
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7462
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.7457
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7456
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7454
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 3 0.7447
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7432
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 4 0.7416
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7414
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7412
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7400
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 4 0.7398
Uridine phosphorylase 2 O95045 UPP2_HUMAN Homo sapiens 4 0.7397
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7391
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7386
Interstitial collagenase P03956 MMP1_HUMAN Homo sapiens 3 0.7371
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7355
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7354
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7348
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 4 0.7339
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7338
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7335
Glucose-1-phosphate thymidylyltransferase 1 P37744 RMLA1_ECOLI Escherichia coli 5 0.7326
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 4 0.7326
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7325
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7320
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7300
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7298
ATP-dependent Clp protease proteolytic subunit P56156 CLPP_HELPY Helicobacter pylori 4 0.7297
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7295
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7285
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7281
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7273
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7263
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 3 0.7262
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7251
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7242
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7238
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7237
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7229
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7225
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7224
Formate--tetrahydrofolate ligase Q2RM91 FTHS_MOOTA Moorella thermoacetica 2 0.7222
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7217
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 4 0.7212
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 5 0.7209
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7204
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7202
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7199
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7187
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7181
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7177
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7176
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7168
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7162
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7159
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7159
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7138
Beta-lactamase Q79MP6 Q79MP6_PSEAI Pseudomonas aeruginosa 2 0.7135
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7131
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7125
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7115
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7113
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7109
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7107
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7098
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7097
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7097
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7083
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7082
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7079
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7074
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7070
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7066
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7057
L-lactate dehydrogenase Q5SJA1 LDH_THET8 Thermus thermophilus 3 0.7053
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7052
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7047
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7040
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7039
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7026
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7025
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7024
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7023
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7010
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7007
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7006
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7004

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