ANPDB

Select a section from the left sidebar

Buddlenol D

Family: Plantae - Umbelliferae
Kingdom: Plantae
Class: Lignan

Canonical Smiles	COc1cc(cc(c1O[C@H]([C@@H](c1cc(OC)c(c(c1)OC)O)O)CO)OC)C1OC[C@H]2[C@@H]1CO[C@@H]2c1cc(OC)c(c(c1)OC)O
InChI	InChI=1S/C33H40O13/c1-38-21-7-16(8-22(39-2)29(21)36)28(35)27(13-34)46-33-25(42-5)11-18(12-26(33)43-6)32-20-15-44-31(19(20)14-45-32)17-9-23(40-3)30(37)24(10-17)41-4/h7-12,19-20,27-28,31-32,34-37H,13-15H2,1-6H3/t19-,20-,27-,28+,31+,32?/m0/s1
InChIKey	CQPUHIMEOUJAQQ-LILUDEBISA-N
Formula	C₃₃H₄₀O₁₃
HBA	13
HBD	4
MW	644.67
Rotatable Bonds	13
TPSA	163.99
LogP	3.7
Number Rings	5
Number Aromatic Rings	3
Heavy Atom Count	46
Formal Charge	0
Fraction CSP3	0.45
Exact Mass	644.25
Number of Lipinski Rule Violations	2

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Eryngium triquetrum	Umbelliferae	Plantae	1094608

Showing of synonyms

Bouzergoune F, Ciavatta M.L, et al. (2016). Phytochemical Study of Eryngium triquetrum: Isolation of Polyacetylenes and Lignans. Planta Med,2016,82(16),1438-1445. [View] [PubMed]

Pubchem: 157010307

No compound-protein relationship available.

SMILES: c1ccccc1CCOc(cc2)ccc2C3OCC(C34)C(OC4)c5ccccc5

Level: 3

Mol. Weight: 644.67 g/mol

SMILES: c1ccccc1CCOc(cc2)ccc2C3OCC(C34)COC4

Level: 2

Mol. Weight: 644.67 g/mol

SMILES: c1ccccc1C(OC2)C(C23)COC3c4ccccc4

Level: 2

Mol. Weight: 644.67 g/mol

SMILES: c1ccccc1CCOc2ccccc2

Level: 1

Mol. Weight: 644.67 g/mol

SMILES: C1OCC(C12)COC2c3ccccc3

Level: 1

Mol. Weight: 644.67 g/mol

SMILES: C1OCC(C12)COC2

Level: 0

Mol. Weight: 644.67 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 644.67 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -5.62
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.690
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: 65.54

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.800
Plasma Protein Binding: 69.52
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 12.510
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.710
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.350
Liver Injury II: Safe
hERG Blockers: Safe
Daphnia Maga: 8.300
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -121195.860
Rat (Acute): 2.460
Rat (Chronic Oral): 3.450
Fathead Minnow: 166.920
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Toxic

General Properties

Boiling Point: 8525.400
Hydration Free Energy: -2.920
Log(D) at pH=7.4: 2.910
Log(P): 0.9
Log S: -4.9
Log(Vapor Pressure): -299.48
Melting Point: 187.96
pKa Acid: 7.15
pKa Basic: 0.61

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.9296
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.9290
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9266
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	4	0.9240
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9187
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9165
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	4	0.9060
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9009
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8887
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	3	0.8877
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.8865
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8826
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8811
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.8805
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8747
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8737
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8697
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.8659
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.8621
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8613
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	4	0.8597
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.8470
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8427
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8422
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8398
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8380
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8379
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8366
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.8358
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8342
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	4	0.8328
Uracil-DNA glycosylase	P20536	UNG_VACCC	Vaccinia virus	4	0.8292
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8286
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.8285
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8280
Uridine phosphorylase	Q9KT71	Q9KT71_VIBCH	Vibrio cholerae serotype O1	4	0.8238
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.8208
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	4	0.8184
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8178
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.8154
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8149
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8123
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	3	0.8120
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8101
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.8089
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8085
Uracil-DNA glycosylase	P13051	UNG_HUMAN	Homo sapiens	4	0.8081
Caffeic acid O-methyltransferase	Q9ZTU2	Q9ZTU2_LOLPR	Lolium perenne	4	0.8077
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.8012
Thymidylate kinase	Q9KQI2	KTHY_VIBCH	Vibrio cholerae serotype O1	4	0.7995
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	4	0.7969
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7967
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.7964
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7960
Trichothecene 15-O-acetyltransferase TRI3	Q9C1B7	TRI3_FUSSP	Fusarium sporotrichioides	3	0.7939
Virulence sensor histidine kinase PhoQ	P0DM80	PHOQ_SALTY	Salmonella typhimurium	4	0.7914
Single-strand selective monofunctional uracil DNA glycosylase	Q9YGN6	SMUG1_XENLA	Xenopus laevis	4	0.7891
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7891
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7886
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7870
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7834
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7832
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7818
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.7792
DNA polymerase III subunit epsilon	P03007	DPO3E_ECOLI	Escherichia coli	3	0.7756
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7716
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.7706
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7703
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7697
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7683
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	4	0.7673
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	3	0.7650
D-mycarose 3-C-methyltransferase	Q194Q4	Q194Q4_STRAA	Streptomyces argillaceus	4	0.7645
Nucleoside phosphorylase, putative	Q57VZ2	Q57VZ2_TRYB2	Trypanosoma brucei brucei	4	0.7620
Glucose-1-phosphate thymidylyltransferase	Q9AGY4	Q9AGY4_ANETH	Aneurinibacillus thermoaerophilus	4	0.7618
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7605
Beta-glucosidase 1A	Q25BW5	BGL1A_PHACH	Phanerodontia chrysosporium	3	0.7598
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7564
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.7559
Uracil-DNA glycosylase	P9WFQ9	UNG_MYCTU	Mycobacterium tuberculosis	4	0.7557
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7546
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7544
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7544
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7537
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7530
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7521
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7510
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7493
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	Q9CCZ4	Y2640_MYCLE	Mycobacterium leprae	3	0.7465
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.7465
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	3	0.7462
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	4	0.7457
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7456
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7454
Nucleoside diphosphate kinase	P15266	NDK_MYXXA	Myxococcus xanthus	3	0.7447
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7432
Rifampin ADP-ribosyl transferase	A0QRS5	A0QRS5_MYCS2	Mycolicibacterium smegmatis155)	4	0.7416
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7414
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7412
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7400
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	4	0.7398
Uridine phosphorylase 2	O95045	UPP2_HUMAN	Homo sapiens	4	0.7397
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7391
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7386
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	3	0.7371
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.7355
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7354
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7348
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	4	0.7339
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7338
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7335
Glucose-1-phosphate thymidylyltransferase 1	P37744	RMLA1_ECOLI	Escherichia coli	5	0.7326
Serine hydroxymethyltransferase	Q7SIB6	Q7SIB6_GEOSE	Geobacillus stearothermophilus	4	0.7326
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7325
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7320
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.7300
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7298
ATP-dependent Clp protease proteolytic subunit	P56156	CLPP_HELPY	Helicobacter pylori	4	0.7297
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7295
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7285
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.7281
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7273
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7263
Aminopeptidase N	P04825	AMPN_ECOLI	Escherichia coli	3	0.7262
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.7251
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7242
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7238
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.7237
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7229
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7225
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	4	0.7224
Formate--tetrahydrofolate ligase	Q2RM91	FTHS_MOOTA	Moorella thermoacetica	2	0.7222
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.7217
Eugenol synthase 1	Q15GI4	EGS1_OCIBA	Ocimum basilicum	4	0.7212
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	5	0.7209
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7204
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7202
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7199
ATP-dependent protease subunit HslV	P0A7B8	HSLV_ECOLI	Escherichia coli	3	0.7187
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7181
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.7177
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	4	0.7176
Phosphoenolpyruvate carboxykinase [GTP]	A5TYT6	PCKG_MYCTA	Mycobacterium tuberculosis	3	0.7168
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7162
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7159
Type IV pilus retractation ATPase PilT	P24559	PILT_PSEAE	Pseudomonas aeruginosa	3	0.7159
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7138
Beta-lactamase	Q79MP6	Q79MP6_PSEAI	Pseudomonas aeruginosa	2	0.7135
dTDP-4-dehydrorhamnose 3,5-epimerase	A0A6L7H6N0	A0A1S0QLH9_BACAN	Bacillus anthracis	3	0.7131
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7125
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.7115
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7113
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7109
NAD-dependent protein deacetylase	Q9WYW0	NPD_THEMA	Thermotoga maritima	3	0.7107
Uncharacterized protein	Q3F0V8	Q3F0V8_BACTI	Bacillus thuringiensis serovar israelensis ATCC 35646	3	0.7098
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7097
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7097
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7083
tRNA (adenine(9)-N1)-methyltransferase	Q4J894	TRM10_SULAC	Sulfolobus acidocaldarius	3	0.7082
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7079
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7074
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7070
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7066
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7057
L-lactate dehydrogenase	Q5SJA1	LDH_THET8	Thermus thermophilus	3	0.7053
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	O50008	METE1_ARATH	Arabidopsis thaliana	2	0.7052
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7047
Oxygenase	Q194P4	Q194P4_STRAA	Streptomyces argillaceus	3	0.7040
Aminoglycoside N(3)-acetyltransferase	A0A3P1UCA6	Q81P86_BACAN	Bacillus anthracis	3	0.7039
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7026
Caffeoyl-CoA O-methyltransferase	Q40313	CAMT_MEDSA	Medicago sativa	3	0.7025
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7024
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.7023
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7010
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7007
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7006
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7004

Download SDF