Threo-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-butoxy-propan-1-ol - Compound Card

Threo-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-butoxy-propan-1-ol

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Threo-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-butoxy-propan-1-ol

Structure
Zoomed Structure
  • Family: Plantae - Umbelliferae
  • Kingdom: Plantae
  • Class: Phenylpropanoid
Canonical Smiles CCCCO[C@@H]([C@@H](c1cccc(c1)OC)CO)c1ccc(c(c1)OC)O
InChI InChI=1S/C21H28O5/c1-4-5-11-26-21(16-9-10-19(23)20(13-16)25-3)18(14-22)15-7-6-8-17(12-15)24-2/h6-10,12-13,18,21-23H,4-5,11,14H2,1-3H3/t18-,21-/m1/s1
InChIKey FCFBTJOYOVMZEP-WIYYLYMNSA-N
Formula C21H28O5
HBA 5
HBD 2
MW 360.45
Rotatable Bonds 10
TPSA 68.15
LogP 4.04
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.43
Exact Mass 360.19
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Eryngium triquetrum Umbelliferae Plantae 1094608

Showing of synonyms

  • Bouzergoune F, Ciavatta M.L, et al. (2016). Phytochemical Study of Eryngium triquetrum: Isolation of Polyacetylenes and Lignans. Planta Med,2016,82(16),1438-1445. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CCc2ccccc2

Level: 1

Mol. Weight: 360.45 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 360.45 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.67
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.6
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.32

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.94
Plasma Protein Binding
75.92
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.77
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.32
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.3
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
5.85
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-1.75
Rat (Acute)
1.89
Rat (Chronic Oral)
2.65
Fathead Minnow
4.51
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
401.46
Hydration Free Energy
-7.32
Log(D) at pH=7.4
3.63
Log(P)
3.2
Log S
-3.96
Log(Vapor Pressure)
-7.37
Melting Point
70.85
pKa Acid
9.26
pKa Basic
4.39
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9515
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9331
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9200
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9130
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9116
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9083
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9082
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9051
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8982
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8948
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8900
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8900
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.8828
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8806
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8798
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8792
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8784
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8781
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8780
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8774
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.8710
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8681
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8673
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8660
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8652
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8645
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8638
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8591
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 3 0.8581
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8571
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8518
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8507
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8468
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8461
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8456
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8438
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8426
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.8404
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8394
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8393
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8385
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8385
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8382
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.8373
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8362
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8356
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8350
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8342
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8329
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.8327
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8326
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8323
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8322
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8319
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8305
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8264
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8241
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8238
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8234
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8227
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8205
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8205
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8193
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8177
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8176
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8169
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8142
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.8137
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8137
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8124
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8116
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 3 0.8112
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8096
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8057
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.8043
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8028
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7964
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7954
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7920
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7914
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7911
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7903
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7892
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7870
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7857
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7855
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7852
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7851
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7851
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7851
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7849
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7844
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7827
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.7825
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7824
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7820
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7807
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7803
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7786
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7783
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7768
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7767
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7766
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7759
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7753
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7749
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7742
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7741
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7722
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7720
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7711
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7708
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7695
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7693
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7681
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7670
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7660
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7658
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 3 0.7651
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7648
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7647
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7645
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7629
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7616
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7612
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7610
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7606
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7603
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7598
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 4 0.7595
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7592
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7580
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7557
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.7554
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7545
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7537
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7530
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7526
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7523
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7517
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 4 0.7503
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7499
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7498
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7493
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7490
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7489
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7487
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7486
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7481
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7480
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7474
Cytochrome P450 2D6 P10635 CP2D6_HUMAN Homo sapiens 3 0.7466
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7458
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7457
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7449
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7447
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7436
Capsid protein VP1 O56137 O56137_9VIRU Adeno-associated virus - 6 3 0.7435
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7428
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7428
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7420
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7420
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7420
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7412
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7398
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7394
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7389
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7388
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7383
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7367
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7366
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7366
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7359
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7355
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7354
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7344
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7343
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7342
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 4 0.7334
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7334
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7330
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7324
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7322
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7321
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7311
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7307
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7307
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7295
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7290
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7289
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7288
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7281
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7271
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7262
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7257
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7256
Cytochrome P450 2D6 P10635 CP2D6_HUMAN Homo sapiens 3 0.7248
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7247
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7247
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7243
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7243
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7242
UTP-monosaccharide-1-phosphate uridylyltransferase D3G6S4 D3G6S4_LEIMA Leishmania major 3 0.7241
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7241
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7240
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7222
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7216
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7216
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7214
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7211
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 3 0.7207
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7206
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7197
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7195
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7195
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7193
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7192
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7191
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7189
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7181
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7178
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7175
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 Q02745 SIA4A_PIG Sus scrofa 4 0.7168
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7168
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7164
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7153
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7150
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7149
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7148
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7147
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7137
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7130
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7125
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7122
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 4 0.7112
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7112
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7107
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7101
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7101
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7101
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7096
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7091
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7087
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7084
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7082
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7081
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7080
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7080
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7079
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7066
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7061
Glutathione S-transferase P46088 GST_NOTSL Nototodarus sloanii 4 0.7059
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 4 0.7054
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7042
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7039
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7034
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7034
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7032
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7025
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7023
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7022
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7022
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7021
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7021
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7017
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7015
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7008
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7005
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7003
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7001

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