P-hydroxyphenylethyl p-coumarate - Compound Card

P-hydroxyphenylethyl p-coumarate

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P-hydroxyphenylethyl p-coumarate

Structure
Zoomed Structure
  • Family: Plantae - Asparagaceae
  • Kingdom: Plantae
  • Class: Benzyl Ester
Canonical Smiles O=C(/C=C/c1ccc(cc1)O)OCCc1ccc(cc1)O
InChI InChI=1S/C17H16O4/c18-15-6-1-13(2-7-15)5-10-17(20)21-12-11-14-3-8-16(19)9-4-14/h1-10,18-19H,11-12H2/b10-5+
InChIKey ZCFLGZLKECDZFW-BJMVGYQFSA-N
Formula C17H16O4
HBA 4
HBD 2
MW 284.31
Rotatable Bonds 5
TPSA 66.76
LogP 2.9
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 284.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Rhodocodon cryptopodus Asparagaceae Plantae 143572

Showing of synonyms

  • Whitmore H, Sishtla K, et al. (2020). Bufadienolides and anti-angiogenic homoisoflavonoids from Rhodocodon cryptopodus, Rhodocodon rotundus and Rhodocodon cyathiformis. Fitoterapia, 2020, 141, 104479. [View]
Pubchem: 16119626
Nmrshiftdb2: 60028106
Bindingdb: 50131679

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C=CC(=O)OCCc2ccccc2

Level: 1

Mol. Weight: 284.31 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 284.31 g/mol

Marginal inhibitory (ec50 of 352.1 μm) against herpes simplex virus type 1 (hsv-1)

Absorption

Caco-2 (logPapp)
-4.82
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.49
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.53

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.81
Plasma Protein Binding
51.13
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.07
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.78
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.0
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.11
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
5.0
Rat (Acute)
1.69
Rat (Chronic Oral)
2.23
Fathead Minnow
4.55
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
410.15
Hydration Free Energy
-10.08
Log(D) at pH=7.4
3.5
Log(P)
3.42
Log S
-3.73
Log(Vapor Pressure)
-7.29
Melting Point
175.17
pKa Acid
9.25
pKa Basic
5.26
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9746
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9550
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9518
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9432
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9222
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9220
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9091
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.9086
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9062
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9000
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8980
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8979
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.8957
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8903
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8868
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.8859
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8850
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8845
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.8814
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8780
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8775
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8766
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8728
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8714
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8688
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8687
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8666
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8614
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8603
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8600
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8582
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8581
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8552
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8545
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8525
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8519
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.8515
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8513
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8499
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8490
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8477
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8448
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 3 0.8364
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8355
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8352
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8333
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8332
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8316
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8313
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.8279
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8274
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8266
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8240
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8233
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8230
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8227
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8213
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8192
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8130
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8120
clade A/E 93TH057 HIV-1 gp120 core A0A0M3KKW9 A0A0M3KKW9_9HIV1 Human immunodeficiency virus 1 3 0.8106
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8096
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8093
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.8076
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.8062
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8059
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8026
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8017
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7998
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7997
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7993
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7982
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7970
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7934
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7928
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7920
S-methyl-5'-thioadenosine phosphorylase Q97W94 MTAP_SACS2 Saccharolobus solfataricus 3 0.7902
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7896
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7861
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7860
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.7844
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7837
Pol protein Q000H7 Q000H7_9HIV1 Human immunodeficiency virus 1 3 0.7825
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7817
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7811
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7801
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7793
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7788
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7788
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7773
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7771
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7767
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7753
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7750
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7747
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7728
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7719
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7718
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7716
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7701
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7698
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7693
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7687
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7685
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 2 0.7672
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7658
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7637
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7633
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7625
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7617
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7617
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7615
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7601
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7599
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7596
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7594
Precorrin-3 methylase O68097 O68097_RHOCA Rhodobacter capsulatus 3 0.7592
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7567
Genome polyprotein C0LMU0 C0LMU0_9FLAV dengue virus type 3 3 0.7564
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7553
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7536
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7532
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7523
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7521
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7518
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7512
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7512
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7505
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7501
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7497
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7491
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7489
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7488
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7466
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7458
Elongation factor Tu 1 P0CE47 EFTU1_ECOLI Escherichia coli 3 0.7444
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7442
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7438
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7434
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7428
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7427
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7408
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7406
YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein Q5SHN1 Q5SHN1_THET8 Thermus thermophilus 3 0.7402
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7400
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7398
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7397
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7396
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7390
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7387
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7377
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7375
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7374
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7372
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7372
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7370
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7369
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7366
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7355
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7355
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7333
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7332
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7331
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7331
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7330
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7328
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7324
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7321
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 4 0.7311
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7310
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7308
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 3 0.7307
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7306
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7302
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7299
Bifunctional dihydrofolate reductase-thymidylate synthase Q07422 DRTS_TOXGO Toxoplasma gondii 3 0.7287
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7287
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7284
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7284
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7284
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7277
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7275
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7270
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7267
LD-carboxypeptidase A0A6L8PVW7 A0A1Q4LWC0_BACAN Bacillus anthracis 3 0.7265
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7265
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7265
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7262
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7260
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7258
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7257
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7253
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7249
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7248
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7247
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7244
tRNA (cytidine-2'-O-)-methyltransferase TrmJ Q4JB16 TRMJ_SULAC Sulfolobus acidocaldarius 3 0.7238
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7236
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7230
Interstitial collagenase P03956 MMP1_HUMAN Homo sapiens 3 0.7229
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7227
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 2 0.7227
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7218
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7209
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7208
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7207
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7207
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 2 0.7205
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7205
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7204
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7203
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7197
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7195
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7188
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7184
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7182
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7181
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7180
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7180
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 3 0.7180
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7176
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7175
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7175
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7165
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7163
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7163
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7163
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7156
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7154
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7154
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7147
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7146
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7140
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7139
Ethylene receptor 1 P49333 ETR1_ARATH Arabidopsis thaliana 3 0.7134
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7128
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7128
Gag-Pol polyprotein P04587 POL_HV1B5 Human immunodeficiency virus type 1 group M subtype B 3 0.7125
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7123
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7122
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 2 0.7121
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7119
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7116
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7116
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7116
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7113
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7109
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7105
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7098
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7098
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7097
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.7096
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7093
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7090
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7089
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7086
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7083
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7081
Holliday junction branch migration complex subunit RuvB Q9PMT7 RUVB_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.7081
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7080
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7079
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7075
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7074
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7073
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.7067
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7066
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7064
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7064
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7063
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7061
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7058
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7057
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7056
Genome polyprotein Q6YMS4 POLG_DEN3S Dengue virus type 3 3 0.7055
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 2 0.7053
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7052
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7050
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7047
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7045
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7045
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7043
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7043
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7043
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7042
cAMP-activated global transcriptional regulator Vfr P55222 VFR_PSEAE Pseudomonas aeruginosa 4 0.7037
Mevalonate kinase P17256 KIME_RAT Rattus norvegicus 3 0.7036
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7036
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7035
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7029
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7028
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7020
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7019
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7017
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7016
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7015
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7014
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7014
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7010
Formate--tetrahydrofolate ligase Q2RM91 FTHS_MOOTA Moorella thermoacetica 2 0.7009
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7007
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7007
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7007
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7004
Bifunctional protein GlmU P43889 GLMU_HAEIN Haemophilus influenzae 4 0.7002
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7002
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7001
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7001

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