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6,7,4′-trimethoxyisoflavone

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Isoflavone

Canonical Smiles	COc1ccc(cc1)c1coc2c(c1=O)cc(c(c2)OC)OC
InChI	InChI=1S/C18H16O5/c1-20-12-6-4-11(5-7-12)14-10-23-15-9-17(22-3)16(21-2)8-13(15)18(14)19/h4-10H,1-3H3
InChIKey	YHXIOAVHEXKZCQ-UHFFFAOYSA-N
Formula	C₁₈H₁₆O₅
HBA	5
HBD	0
MW	312.32
Rotatable Bonds	4
TPSA	57.9
LogP	3.49
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	23
Formal Charge	0
Fraction CSP3	0.17
Exact Mass	312.1
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Millettia lasiantha	Leguminosae/Fabaceae	Plantae	185969

Showing of synonyms

Daniel B, Solomon D, et al. (2021). A coumestan and a coumaronochromone from Millettia lasiantha. Biochemical Systematics and Ecology, 2021, 97,104277. [View]

Pubchem: 688655

Cas: 798-61-8

Zinc: ZINC000000057640

Nmrshiftdb2: 60058256

Chembl: CHEMBL12673

Comptox: DTXSID60350937

CPRiL: 107111

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 312.32 g/mol

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 312.32 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 312.32 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.7
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.350
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.65

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.370
Plasma Protein Binding: 77.18
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 7.730
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 2.090
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 1.190
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.340
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.200
Rat (Acute): 2.080
Rat (Chronic Oral): 1.840
Fathead Minnow: 5.180
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Toxic
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 429.720
Hydration Free Energy: -10.080
Log(D) at pH=7.4: 2.750
Log(P): 3.13
Log S: -4.64
Log(Vapor Pressure): -6.66
Melting Point: 167.73
pKa Acid: 9.18
pKa Basic: 1.44

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9838
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.9658
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.9612
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9595
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.9594
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.9500
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9463
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9426
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9421
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9392
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9331
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.9297
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.9263
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.9188
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.9141
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.9122
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.9109
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9109
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.9042
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	3	0.9007
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.8974
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.8944
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.8896
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8862
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.8838
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	3	0.8782
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8756
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8756
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.8748
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8741
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8676
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8659
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8617
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8600
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8510
Cyclic nucleotide-binding domain-containing protein	E0RR11	E0RR11_SPITD	Spirochaeta thermophila	3	0.8496
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8472
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8471
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8426
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.8351
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.8332
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.8297
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	4	0.8271
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8252
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8243
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.8243
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.8224
Isoflavone-7-O-methyltransferase 8	O24529	7OMT8_MEDSA	Medicago sativa	4	0.8221
Odorant-binding protein	P81245	OBP_PIG	Sus scrofa	3	0.8178
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.8173
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.8134
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.8074
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8067
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.8066
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.8058
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.8049
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.8023
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8020
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7992
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	3	0.7958
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7940
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7931
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7928
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7901
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7863
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7854
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7806
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.7804
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7800
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7796
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7786
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7771
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7766
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7724
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7716
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7709
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7709
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7708
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7702
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.7702
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7685
Farnesyl pyrophosphate synthase	P14324	FPPS_HUMAN	Homo sapiens	2	0.7682
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7677
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7669
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7667
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7664
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7663
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7658
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7648
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7646
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7635
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7602
Cyclic nucleotide-gated potassium channel mll3241	Q98GN8	CNGK1_RHILO	Mesorhizobium japonicum)	3	0.7600
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7584
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7581
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7578
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	2	0.7575
Beta sliding clamp	P0A988	DPO3B_ECOLI	Escherichia coli	2	0.7559
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.7557
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7556
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7548
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7546
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7545
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7534
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7503
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7497
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7484
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7481
Putative protease I	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron	2	0.7480
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7473
Probable esterase KAI2	Q9SZU7	KAI2_ARATH	Arabidopsis thaliana	3	0.7471
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7470
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7470
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7467
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7466
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7464
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	2	0.7464
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7463
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7455
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	2	0.7454
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7451
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	2	0.7443
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7432
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7431
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7411
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7400
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7392
Bromodomain protein, putative	Q8I240	Q8I240_PLAF7	Plasmodium falciparum	4	0.7387
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7387
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7386
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7381
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7361
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7354
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	2	0.7346
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7343
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7337
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7323
Matrix metalloproteinase-9	P14780	MMP9_HUMAN	Homo sapiens	2	0.7322
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7319
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.7313
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	2	0.7312
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7311
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7305
Beta-ketoacyl-[acyl-carrier-protein] synthase III	Q820T1	FABH_ENTFA	Enterococcus faecalis	2	0.7305
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7304
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7303
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7301
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7296
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7291
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7287
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7287
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7282
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7278
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7269
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7269
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	2	0.7263
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7249
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7248
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7246
Beta-glucosidase 12	B8AVF0	BGL12_ORYSI	Oryza sativa subsp. indica	2	0.7245
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7243
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	2	0.7228
Cyclic AMP receptor protein	Q5SID7	CRP_THET8	Thermus thermophilus	3	0.7228
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7224
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	3	0.7223
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7220
Beta-secretase 2	Q9Y5Z0	BACE2_HUMAN	Homo sapiens	2	0.7215
Renin	P00797	RENI_HUMAN	Homo sapiens	2	0.7215
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7211
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7210
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7208
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7205
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7201
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7198
Ketimine reductase mu-crystallin	O54983	CRYM_MOUSE	Mus musculus	2	0.7195
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7185
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	2	0.7185
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7183
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7181
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7178
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7176
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7170
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7167
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.7166
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7164
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	2	0.7160
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7158
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7149
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7147
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	2	0.7144
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7139
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7135
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	2	0.7132
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7128
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	2	0.7117
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	2	0.7115
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7103
Uridine phosphorylase	Q9KT71	Q9KT71_VIBCH	Vibrio cholerae serotype O1	3	0.7101
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	2	0.7095
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.7093
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7088
Nucleoside phosphorylase, putative	Q57VZ2	Q57VZ2_TRYB2	Trypanosoma brucei brucei	3	0.7080
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7078
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	2	0.7076
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	2	0.7070
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7063
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	2	0.7062
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7060
Nucleoside diphosphate kinase	P15266	NDK_MYXXA	Myxococcus xanthus	2	0.7057
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7056
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	3	0.7053
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	2	0.7053
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7051
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7048
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	2	0.7046
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	3	0.7045
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7044
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7041
Biphenyl-2,3-diol 1,2-dioxygenase	P47228	BPHC_PARXL	Paraburkholderia xenovorans	2	0.7035
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.7034
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7034
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7029
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7029
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7028
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7028
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7027
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7013
Collagenase 3	P45452	MMP13_HUMAN	Homo sapiens	3	0.7008
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	3	0.7005
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7004
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7004

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