(R)-5,7-dihydroxy-8-methoxy-3-(4’-hydroxybenzyl)-4-chromanone - Compound Card

(R)-5,7-dihydroxy-8-methoxy-3-(4’-hydroxybenzyl)-4-chromanone

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(R)-5,7-dihydroxy-8-methoxy-3-(4’-hydroxybenzyl)-4-chromanone

Structure
Zoomed Structure
  • Family: Plantae - Hyacinthaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Homoisoflavonoid
Canonical Smiles COc1c(O)cc(c2c1OC[C@H](C2=O)Cc1ccc(cc1)O)O
InChI InChI=1S/C17H16O6/c1-22-16-13(20)7-12(19)14-15(21)10(8-23-17(14)16)6-9-2-4-11(18)5-3-9/h2-5,7,10,18-20H,6,8H2,1H3/t10-/m1/s1
InChIKey ZAZTVPBMNCLNOB-SNVBAGLBSA-N
Formula C17H16O6
HBA 6
HBD 3
MW 316.31
Rotatable Bonds 3
TPSA 96.22
LogP 2.25
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 316.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Eucomis zambesiaca Hyacinthaceae Plantae 208122

Showing of synonyms

  • Sihra JK, Thumser AE, et al. (2015). Constituents of Bulbs of three Species of the Hyacinthaceae (Hyacinthoideae): Eucomis vandermerwei, E. zambesiaca and Resnova humifusa. Natural Product Communications, 2015,10 (7), 1207-1209. [View]
Pubchem: 132555989
Nmrshiftdb2: 70037278

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CC(C2=O)COc(c23)cccc3

Level: 1

Mol. Weight: 316.31 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 316.31 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 316.31 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.87
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.880
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.95

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.980
Plasma Protein Binding
76.76
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
11.670
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.620
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.590
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.290
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.190
Rat (Acute)
2.140
Rat (Chronic Oral)
3.040
Fathead Minnow
4.290
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
426.220
Hydration Free Energy
-8.840
Log(D) at pH=7.4
2.460
Log(P)
2.29
Log S
-4.69
Log(Vapor Pressure)
-7.69
Melting Point
188.71
pKa Acid
7.49
pKa Basic
4.43
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9548
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9375
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.9199
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9188
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9178
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9172
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9172
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9100
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9087
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9076
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9070
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9058
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8972
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8965
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8914
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8907
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.8899
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8892
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8875
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8859
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8827
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 4 0.8772
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8746
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8738
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8735
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8734
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8723
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8721
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8700
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8695
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8641
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8623
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8622
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8571
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8568
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8563
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8521
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.8513
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.8512
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8512
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8495
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8491
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8491
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8471
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.8461
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8455
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8435
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8433
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8398
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8390
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 3 0.8390
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8316
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8274
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8265
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.8256
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8249
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8247
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8217
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8175
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Q9NTG7 SIR3_HUMAN Homo sapiens 5 0.8170
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8163
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8145
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8141
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8121
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8116
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.8101
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8095
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8060
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8043
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8034
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.8019
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8017
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.8016
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8016
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8015
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8013
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7977
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7974
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7968
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7967
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7964
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7957
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7932
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7932
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.7919
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7919
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7917
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7913
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7906
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7906
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7896
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7886
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7861
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7854
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7851
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7821
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 4 0.7806
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7795
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7794
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7792
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7791
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7767
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7755
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7754
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7749
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7743
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7735
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7712
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7710
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7709
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7693
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7691
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7690
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7653
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7641
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7636
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7634
Regucalcin Q64374 RGN_MOUSE Mus musculus 3 0.7620
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7613
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7613
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7609
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7600
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7596
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7596
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7590
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7571
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7564
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7553
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7541
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7539
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7519
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7516
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7513
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7506
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7500
Ephrin type-A receptor 3 P29320 EPHA3_HUMAN Homo sapiens 4 0.7497
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7485
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7481
Cyclin-G-associated kinase O14976 GAK_HUMAN Homo sapiens 4 0.7480
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7477
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7467
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7461
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7460
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7456
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7451
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7448
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7448
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7438
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.7438
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7435
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7431
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7417
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7413
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7409
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7407
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7393
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7393
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7388
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7387
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7374
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7369
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7366
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7362
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7361
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7357
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7357
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 4 0.7356
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7351
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7346
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7335
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7331
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7327
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7324
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 5 0.7322
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7321
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7317
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7311
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7309
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7305
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7302
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7298
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7295
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7290
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7288
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7281
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7276
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 5 0.7275
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7275
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7275
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7273
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7272
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7269
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7265
UTP-monosaccharide-1-phosphate uridylyltransferase D3G6S4 D3G6S4_LEIMA Leishmania major 3 0.7261
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7260
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7249
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7249
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 4 0.7247
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7246
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7239
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7239
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7239
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7238
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7237
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7233
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7227
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7226
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7225
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7222
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7214
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7212
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7194
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7190
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7182
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 3 0.7176
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 4 0.7167
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7162
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7162
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7160
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7157
Beta-lactamase P00811 AMPC_ECOLI Escherichia coli 3 0.7153
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.7150
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7149
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7148
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7146
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7146
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7144
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7142
Antiviral protein I P10297 RIP1_PHYAM Phytolacca americana 4 0.7139
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7138
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7137
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7135
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7131
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7127
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7125
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7122
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 2 0.7110
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7100
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7096
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7094
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7094
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7092
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7091
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7089
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7087
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7085
Probable bifunctional SAT/APS kinase O67174 SATC_AQUAE Aquifex aeolicus 3 0.7080
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7076
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7068
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7067
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7064
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7062
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7062
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7059
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7059
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7057
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7056
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7049
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7048
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7038
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 4 0.7037
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7036
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7036
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7033
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7031
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7027
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7027
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7026
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7017
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7012
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7011
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7011
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7010
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7008
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7006

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