(R)-5,7-dihydroxy-6-methoxy-3-(4’-hydroxybenzyl)-4-chromanone - Compound Card

(R)-5,7-dihydroxy-6-methoxy-3-(4’-hydroxybenzyl)-4-chromanone

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(R)-5,7-dihydroxy-6-methoxy-3-(4’-hydroxybenzyl)-4-chromanone

Structure
Zoomed Structure
  • Family: Plantae - Hyacinthaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Homoisoflavonoid
Canonical Smiles COc1c(O)cc2c(c1O)C(=O)[C@@H](CO2)Cc1ccc(cc1)O
InChI InChI=1S/C17H16O6/c1-22-17-12(19)7-13-14(16(17)21)15(20)10(8-23-13)6-9-2-4-11(18)5-3-9/h2-5,7,10,18-19,21H,6,8H2,1H3/t10-/m1/s1
InChIKey CGCVUMRAPMFWDT-SNVBAGLBSA-N
Formula C17H16O6
HBA 6
HBD 3
MW 316.31
Rotatable Bonds 3
TPSA 96.22
LogP 2.25
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 316.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Eucomis zambesiaca Hyacinthaceae Plantae 208122

Showing of synonyms

  • Sihra JK, Thumser AE, et al. (2015). Constituents of Bulbs of three Species of the Hyacinthaceae (Hyacinthoideae): Eucomis vandermerwei, E. zambesiaca and Resnova humifusa. Natural Product Communications, 2015,10 (7), 1207-1209. [View]
Pubchem: 638288
Nmrshiftdb2: 60030369

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CC(C2=O)COc(c23)cccc3

Level: 1

Mol. Weight: 316.31 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 316.31 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 316.31 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.73
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.850
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.82

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.050
Plasma Protein Binding
79.64
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
11.190
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.830
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.990
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.000
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.710
Rat (Acute)
2.220
Rat (Chronic Oral)
3.050
Fathead Minnow
4.250
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
423.010
Hydration Free Energy
-8.850
Log(D) at pH=7.4
2.570
Log(P)
2.13
Log S
-4.66
Log(Vapor Pressure)
-7.65
Melting Point
188.5
pKa Acid
6.87
pKa Basic
4.63
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9372
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9281
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9280
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9255
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9045
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9039
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9009
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8979
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8955
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8909
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.8896
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 4 0.8884
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8882
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8869
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8856
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8853
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8845
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8759
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8758
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8757
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 4 0.8755
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.8723
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8704
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8697
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8695
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8690
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8684
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8667
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8665
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8662
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8649
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8636
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8606
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8581
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8564
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8547
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8525
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8515
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8513
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8506
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8488
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8427
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8411
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 3 0.8409
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8393
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8391
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8378
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8343
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8292
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8259
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8251
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8237
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8234
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8233
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8229
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8201
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8182
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.8147
Purine nucleoside phosphorylase Q8DTU4 Q8DTU4_STRMU Streptococcus mutans serotype c 4 0.8147
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8143
Purine nucleoside phosphorylase P9WP00 PUNA_MYCTO Mycobacterium tuberculosis 4 0.8132
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8123
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.8114
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8097
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8090
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.8085
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8074
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8065
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8063
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8052
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8043
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8042
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 4 0.8026
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8018
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8013
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8001
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8000
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7995
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7992
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7953
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7944
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.7933
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7929
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7926
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7907
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7890
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7881
Purine nucleoside phosphorylase B9JYS2 B9JYS2_AGRVS Agrobacterium vitis 4 0.7857
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7856
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7852
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7848
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7836
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7828
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7827
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7823
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7822
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 4 0.7800
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7796
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7786
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7762
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.7743
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7741
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7729
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7707
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7702
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7695
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7681
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7677
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7666
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7665
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7659
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7657
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7657
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7654
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7650
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7642
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7638
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7636
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7618
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7576
Cyclin-G-associated kinase O14976 GAK_HUMAN Homo sapiens 4 0.7572
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7562
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7562
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7560
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7558
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7546
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7545
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7539
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7538
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7534
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 4 0.7530
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7525
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7524
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7517
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7511
S-methyl-5'-thioinosine phosphorylase Q9HZK1 MTIP_PSEAE Pseudomonas aeruginosa 4 0.7507
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.7506
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7506
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7502
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7500
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7498
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7496
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7483
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 4 0.7475
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7459
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7459
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7454
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7454
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7449
Phenolphthiocerol/phthiocerol polyketide synthase subunit C P96202 PPSC_MYCTU Mycobacterium tuberculosis 3 0.7443
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7432
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7418
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7414
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7409
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7398
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7396
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7393
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7380
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7372
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7370
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7368
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7368
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7366
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7365
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7363
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7359
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7351
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7351
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7348
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7343
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 4 0.7337
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7319
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7310
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7309
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7306
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7305
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7305
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7302
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7301
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7297
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7289
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Q9X112 METE_THEMA Thermotoga maritima 5 0.7288
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7288
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7286
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7281
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7273
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7267
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7265
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7258
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7256
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7256
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7250
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7244
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7243
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7242
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7238
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7235
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 4 0.7229
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7229
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.7224
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7218
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.7213
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7212
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7209
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7209
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7208
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7198
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7194
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7187
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7183
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7183
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 5 0.7182
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7181
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7176
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7175
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7170
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7167
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7160
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7157
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7146
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7142
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7138
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7134
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7118
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7116
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7106
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7095
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7092
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7085
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7084
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7083
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7080
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7077
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7075
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7067
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7066
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7063
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.7060
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7059
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7050
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7046
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7045
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 4 0.7043
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7031
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7030
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 2 0.7026
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 4 0.7024
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7024
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7024
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7019
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7013
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7002

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