(R)-7,8-dimethoxy-5-hydroxy-3-(4’-hydroxybenzyl)-4-chromanone - Compound Card

(R)-7,8-dimethoxy-5-hydroxy-3-(4’-hydroxybenzyl)-4-chromanone

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(R)-7,8-dimethoxy-5-hydroxy-3-(4’-hydroxybenzyl)-4-chromanone

Structure
Zoomed Structure
  • Family: Plantae - Hyacinthaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Homoisoflavonoid
Canonical Smiles COc1c(OC)cc(c2c1OC[C@H](C2=O)Cc1ccc(cc1)O)O
InChI InChI=1S/C18H18O6/c1-22-14-8-13(20)15-16(21)11(9-24-18(15)17(14)23-2)7-10-3-5-12(19)6-4-10/h3-6,8,11,19-20H,7,9H2,1-2H3/t11-/m1/s1
InChIKey GMCVGMAGOGOINY-LLVKDONJSA-N
Formula C18H18O6
HBA 6
HBD 2
MW 330.34
Rotatable Bonds 4
TPSA 85.22
LogP 2.55
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.28
Exact Mass 330.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Resnova humifusa Hyacinthaceae Plantae 208147

Showing of synonyms

  • Sihra JK, Thumser AE, et al. (2015). Constituents of Bulbs of three Species of the Hyacinthaceae (Hyacinthoideae): Eucomis vandermerwei, E. zambesiaca and Resnova humifusa. Natural Product Communications, 2015,10 (7), 1207-1209. [View]
Pubchem: 638293
Nmrshiftdb2: 70000189

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CC(C2=O)COc(c23)cccc3

Level: 1

Mol. Weight: 330.34 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 330.34 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 330.34 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.52
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.740
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.19

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.110
Plasma Protein Binding
72.25
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
10.980
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.090
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.910
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.030
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.360
Rat (Acute)
1.860
Rat (Chronic Oral)
2.510
Fathead Minnow
4.540
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
426.180
Hydration Free Energy
-8.660
Log(D) at pH=7.4
2.490
Log(P)
2.46
Log S
-4.8
Log(Vapor Pressure)
-7.66
Melting Point
150.32
pKa Acid
7.66
pKa Basic
3.58
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9847
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9346
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9296
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9288
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9274
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9271
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9271
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9216
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9190
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9158
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9122
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9064
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9061
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9049
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9048
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9040
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.9037
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8977
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8909
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8865
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8855
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8814
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8772
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8766
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8758
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8725
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8698
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8650
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.8650
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8640
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8578
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8566
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8562
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8550
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8538
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8534
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8531
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8520
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8462
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8445
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 3 0.8434
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8400
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.8394
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8383
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8363
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8338
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8331
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8278
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8270
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8219
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8207
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 3 0.8181
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8158
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8151
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8136
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8134
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.8119
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.8117
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8049
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8046
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8022
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8019
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8004
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8002
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7993
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7990
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7984
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7982
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7956
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7954
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7947
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7933
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7915
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7896
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7887
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7880
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7861
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7835
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7831
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7824
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 4 0.7818
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7815
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7806
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7799
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7798
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7798
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7797
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7776
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7766
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7749
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7741
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7739
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7726
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7722
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7715
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7715
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7709
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7707
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7684
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7681
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7680
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7678
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7678
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7673
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7672
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7659
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7648
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7647
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7644
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7643
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7640
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7632
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7623
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7622
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7621
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7611
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7600
Cyclin-G-associated kinase O14976 GAK_HUMAN Homo sapiens 4 0.7593
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7592
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7589
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7584
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7581
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7570
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7566
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7565
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7562
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7560
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7550
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7544
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7541
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7531
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7529
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7523
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7521
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7520
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7513
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7508
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7505
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7499
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7496
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7486
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7483
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7463
Glycogenin-1 P46976 GLYG_HUMAN Homo sapiens 3 0.7459
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7454
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7447
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7447
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7443
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7442
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7440
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7434
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7429
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7426
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.7424
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7419
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7414
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7414
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7413
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7411
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 3 0.7408
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 4 0.7404
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7404
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7379
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7379
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7374
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7372
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7369
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7367
Calmodulin-like domain protein kinase Q3HNM4 Q3HNM4_EIMTE Eimeria tenella 4 0.7367
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7365
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7363
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7362
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7361
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7351
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 5 0.7347
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7347
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7341
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7341
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7339
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7338
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 4 0.7338
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7335
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7329
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 4 0.7329
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7325
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7323
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7312
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7308
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7306
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7306
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7305
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7304
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7301
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7292
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7284
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7281
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7280
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7279
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7276
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7257
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7255
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7251
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7238
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7237
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7237
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7234
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7234
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7230
Elongation factor Tu 1 P0CE47 EFTU1_ECOLI Escherichia coli 3 0.7228
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7221
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7219
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7214
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7213
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7209
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7209
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7198
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7195
Beta-lactamase P00811 AMPC_ECOLI Escherichia coli 3 0.7187
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7187
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7186
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.7180
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7172
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7169
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7167
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7164
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7164
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7164
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7157
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7152
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7145
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7145
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7143
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7140
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7131
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7126
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7122
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7117
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7117
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7113
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7107
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7100
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7098
Probable bifunctional SAT/APS kinase O67174 SATC_AQUAE Aquifex aeolicus 3 0.7097
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7096
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7092
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7086
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7082
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7076
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7074
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7070
Serine endoprotease DegS P0AEE3 DEGS_ECOLI Escherichia coli 4 0.7068
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7062
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7061
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7060
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7059
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7058
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7056
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7052
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7051
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7043
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7041
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7039
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7038
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7034
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7031
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 4 0.7018
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7011
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7009

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