4,4’-dihydroxy-2’,6’-dimethoxychalcone - Compound Card

4,4’-dihydroxy-2’,6’-dimethoxychalcone

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4,4’-dihydroxy-2’,6’-dimethoxychalcone

Structure
Zoomed Structure
  • Family: Plantae - Hyacinthaceae
  • Kingdom: Plantae
  • Class: Chalcone
Canonical Smiles COc1cc(O)cc(c1C(=O)/C=C/c1ccc(cc1)O)OC
InChI InChI=1S/C17H16O5/c1-21-15-9-13(19)10-16(22-2)17(15)14(20)8-5-11-3-6-12(18)7-4-11/h3-10,18-19H,1-2H3/b8-5+
InChIKey SJULMVKFURWCFM-VMPITWQZSA-N
Formula C17H16O5
HBA 5
HBD 2
MW 300.31
Rotatable Bonds 5
TPSA 75.99
LogP 3.01
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 300.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Resnova humifusa Hyacinthaceae Plantae 208147

Showing of synonyms

  • Sihra JK, Thumser AE, et al. (2015). Constituents of Bulbs of three Species of the Hyacinthaceae (Hyacinthoideae): Eucomis vandermerwei, E. zambesiaca and Resnova humifusa. Natural Product Communications, 2015,10 (7), 1207-1209. [View]
Pubchem: 11022960
Chebi: 174868
Nmrshiftdb2: 70003209

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 300.31 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 300.31 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.43
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.520
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.07

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.070
Plasma Protein Binding
48.16
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.480
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.560
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.150
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
6.570
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.710
Rat (Acute)
2.020
Rat (Chronic Oral)
2.840
Fathead Minnow
4.870
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
417.210
Hydration Free Energy
-9.970
Log(D) at pH=7.4
2.410
Log(P)
2.41
Log S
-6.19
Log(Vapor Pressure)
-6.97
Melting Point
173.91
pKa Acid
8.66
pKa Basic
3.97
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9508
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9451
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9340
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9260
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9240
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9238
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9212
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9200
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9153
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9145
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9133
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9125
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9116
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.8992
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8990
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8986
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8982
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8968
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8954
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8950
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8814
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8782
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8779
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8754
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8698
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8680
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8629
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8624
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8616
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 4 0.8613
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8589
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.8587
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8569
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8551
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8487
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8479
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8475
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.8467
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8454
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8437
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.8430
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8416
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8395
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8384
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8358
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8316
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8302
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 5 0.8258
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8250
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8219
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8215
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8211
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8179
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8144
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8141
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8120
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8089
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8081
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.8026
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7992
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7990
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7987
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7976
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7961
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7957
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7943
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7883
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7879
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7855
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.7853
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7790
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7790
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7784
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7727
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7707
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Q9NTG7 SIR3_HUMAN Homo sapiens 4 0.7687
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7680
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7679
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7676
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7667
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7664
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7655
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7645
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7616
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7613
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7571
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7544
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7540
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7538
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7536
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7535
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.7518
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7514
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7507
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7482
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7471
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7469
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7464
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7459
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7456
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7456
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7447
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7441
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7436
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7419
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7410
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7403
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7392
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7392
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7377
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7377
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7369
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7366
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7361
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7353
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7352
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7346
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7336
Botulinum neurotoxin type B P10844 BXB_CLOBO Clostridium botulinum 3 0.7336
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7332
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7317
Putative N-acetyl glucosaminyl transferase Q6U8B0 Q6U8B0_RAOTE Raoultella terrigena 3 0.7314
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7312
Rac-like GTP-binding protein ARAC7 O82480 RAC7_ARATH Arabidopsis thaliana 3 0.7308
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7304
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7304
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7301
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7292
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7291
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7282
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7281
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7272
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7265
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7248
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7247
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8ZMF7 ISPF_SALTY Salmonella typhimurium 3 0.7247
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7237
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7237
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7236
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7231
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7228
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7227
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7224
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7216
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7213
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7212
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7206
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7205
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7184
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7183
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7174
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7169
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7168
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7162
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7157
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7156
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7153
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7151
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7140
Putative pteridine reductase 2 Q8I814 Q8I814_TRYCR Trypanosoma cruzi 4 0.7139
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7129
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7121
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7113
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7112
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7109
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7101
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7101
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7087
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7083
Clathrin heavy chain 1 Q00610 CLH1_HUMAN Homo sapiens 3 0.7080
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7080
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7076
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7076
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7075
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7060
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7055
Cytidylate kinase Q5SL35 KCY_THET8 Thermus thermophilus 3 0.7039
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7037
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7031
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7026
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7025
Petrobactin biosynthesis protein AsbB Q81RQ8 Q81RQ8_BACAN Bacillus anthracis 3 0.7023
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7021
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7020
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7016
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7016
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7009

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