Hexyl (E)−3-(4–hydroxy-3-methoxyphenyl)−2-propenoate - Compound Card

Hexyl (E)−3-(4–hydroxy-3-methoxyphenyl)−2-propenoate

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Hexyl (E)−3-(4–hydroxy-3-methoxyphenyl)−2-propenoate

Structure
Zoomed Structure
  • Family: Euphorbiaceae
  • Kingdom: Plantae
  • Class: Phenolic
    • Subclass: Phenolic Ester
Canonical Smiles c1(c(ccc(c1)/C=C/C(=O)OCCCCCC)O)OC
InChI InChI=1S/C16H22O4/c1-3-4-5-6-11-20-16(18)10-8-13-7-9-14(17)15(12-13)19-2/h7-10,12,17H,3-6,11H2,1-2H3/b10-8+
InChIKey GSUPPTOWPNFMPI-CSKARUKUSA-N
Formula C16H22O4
HBA 4
HBD 1
MW 278.35
Rotatable Bonds 8
TPSA 55.76
LogP 3.54
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.44
Exact Mass 278.15
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Euphorbia grandicornis Euphorbiaceae Plantae 334676

Showing of synonyms

  • Kemboi D, Langat MK, et al. (2021). In vitro cytotoxic effects of chemical constituents of Euphorbia grandicornis Blanc against breast cancer cells. Scientific African, 2021, 14, e01002. [View]
Pubchem: 49864065

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-4.74
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.3
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.89

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.64
Plasma Protein Binding
33.91
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.91
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.31
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.85
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
5.28
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
5.33
Rat (Acute)
1.93
Rat (Chronic Oral)
2.38
Fathead Minnow
4.3
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
346.31
Hydration Free Energy
-7.47
Log(D) at pH=7.4
3.97
Log(P)
4.47
Log S
-4.27
Log(Vapor Pressure)
-5.19
Melting Point
54.53
pKa Acid
9.08
pKa Basic
5.47
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9621
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9521
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9471
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9333
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9263
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9137
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9115
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.9106
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.9066
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.9056
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9009
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8986
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8857
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8816
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 4 0.8787
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8779
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8753
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8723
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8719
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8692
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8532
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8439
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8420
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8388
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8374
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8350
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8314
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8266
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8247
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8233
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.8211
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8194
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8177
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8144
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8136
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8112
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8104
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8104
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7980
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7953
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7932
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7881
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7872
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7864
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7833
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 2 0.7819
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7818
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7789
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7783
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 4 0.7754
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7740
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7699
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7666
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7654
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7648
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7636
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 2 0.7623
Ras-related protein Rap-1b P61224 RAP1B_HUMAN Homo sapiens 4 0.7597
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7593
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7582
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 3 0.7554
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7548
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7542
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7537
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7526
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7526
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7522
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7520
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7512
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7511
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7499
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7497
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7472
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7469
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7465
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7456
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7456
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7448
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7437
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7428
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7412
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7400
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7397
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7392
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7390
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7378
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7367
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7366
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7363
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7351
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7349
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7346
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7344
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7340
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7325
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7319
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7315
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7312
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7309
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Q8GZB6 SUVH4_ARATH Arabidopsis thaliana 3 0.7294
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7294
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7280
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7275
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7267
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7266
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7261
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7259
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7253
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7244
Histone-lysine N-methyltransferase 2C Q8NEZ4 KMT2C_HUMAN Homo sapiens 3 0.7242
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7242
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7230
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7230
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7227
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7227
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7221
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7221
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 2 0.7217
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7217
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7207
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7207
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7207
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7206
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7191
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7187
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7185
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7177
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7158
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7156
Transitional endoplasmic reticulum ATPase Q01853 TERA_MOUSE Mus musculus 3 0.7155
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 4 0.7149
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7147
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7147
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7144
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7140
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7138
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7135
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7132
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7127
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7123
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7123
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7122
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7122
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7121
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7118
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7110
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7109
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7109
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7105
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7100
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7099
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.7091
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7084
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7084
Sodium/potassium-transporting ATPase subunit alpha Q4H132 Q4H132_SQUAC Squalus acanthias 2 0.7082
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7081
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7078
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7077
Bifunctional protein GAL10 P04397 GAL10_YEAST Saccharomyces cerevisiae 4 0.7075
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7067
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7065
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7063
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7063
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7059
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7059
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7058
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7055
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7054
Homoserine kinase Q58504 KHSE_METJA Methanocaldococcus jannaschii 4 0.7049
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7048
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 2 0.7042
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7038
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7033
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 3 0.7032
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7030
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7025
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7020
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7015
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7012
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7009
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7006
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7005
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase P47229 BPHD_PARXL Paraburkholderia xenovorans 2 0.7005
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7004
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7004
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7002
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7001
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 2 0.7001

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