Urgineol C - Compound Card

Urgineol C

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Urgineol C

Structure
Zoomed Structure
  • Family: Liliaceae
  • Kingdom: Plantae
  • Class: Phenolic
    • Subclass: Alkylresorcinol
Canonical Smiles CCCCCCCCCCCCCCCCCCCCc1cc(OC)cc(c1)OC
InChI InChI=1S/C28H50O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-26-23-27(29-2)25-28(24-26)30-3/h23-25H,4-22H2,1-3H3
InChIKey DENRSFKYAYSSKH-UHFFFAOYSA-N
Formula C28H50O2
HBA 2
HBD 0
MW 418.71
Rotatable Bonds 21
TPSA 18.46
LogP 9.29
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 30
Formal Charge 0
Fraction CSP3 0.79
Exact Mass 418.38
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Urginea indica Liliaceae Plantae 81800

Showing of synonyms

  • Mikail HG, Karvouni H, et al. (2015). Newalkylresorcinols froma lipophilic extract of Urginea indica L. bulbs showing experimental trauma healing activity. Fitoterapia,2015,101,41-45. [View]

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.24
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-3.75
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
-3.93

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
2.39
Plasma Protein Binding
41.81
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.56
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
2.52
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.83
Liver Injury II
Safe
hERG Blockers
Toxic
Daphnia Maga
6.56
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-14.7
Rat (Acute)
1.87
Rat (Chronic Oral)
2.56
Fathead Minnow
4.65
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
463.22
Hydration Free Energy
-3.77
Log(D) at pH=7.4
7.45
Log(P)
12.31
Log S
-5.98
Log(Vapor Pressure)
-7.65
Melting Point
47.99
pKa Acid
12.11
pKa Basic
3.91
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.9955
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9827
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9732
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.9183
Peridinin-chlorophyll a protein, high-salt form O76183 O76183_AMPCA Amphidinium carterae 3 0.8966
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8894
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8720
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8596
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7981
Uridine phosphorylase P12758 UDP_ECOLI Escherichia coli 3 0.7967
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 2 0.7954
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7941
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7934
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7909
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7896
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7880
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7865
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7824
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7813
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 3 0.7800
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7790
Thymidylate kinase Q9KQI2 KTHY_VIBCH Vibrio cholerae serotype O1 3 0.7763
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7758
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7755
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 2 0.7753
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7747
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7743
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7740
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7737
LL-diaminopimelate aminotransferase, chloroplastic Q93ZN9 DAPAT_ARATH Arabidopsis thaliana 2 0.7720
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7710
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7710
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7691
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7690
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7682
DNA topoisomerase 1 P06612 TOP1_ECOLI Escherichia coli 3 0.7671
Uracil-DNA glycosylase P20536 UNG_VACCC Vaccinia virus 3 0.7670
Uracil-DNA glycosylase P13051 UNG_HUMAN Homo sapiens 3 0.7646
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 2 0.7633
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7633
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7633
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7629
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.7626
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 3 0.7603
Uridine phosphorylase 2 O95045 UPP2_HUMAN Homo sapiens 3 0.7599
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7590
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7589
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7566
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7565
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7562
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7560
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7559
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7547
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7537
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7533
Uracil-DNA glycosylase P9WFQ9 UNG_MYCTU Mycobacterium tuberculosis 3 0.7530
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7524
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7520
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7517
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7507
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7505
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7492
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7491
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7484
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7475
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7469
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7468
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7468
Tryptophan synthase beta chain 2 Q97TX6 TRPB2_SACS2 Saccharolobus solfataricus 2 0.7458
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7457
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7456
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7454
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.7445
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7444
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 2 0.7440
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 3 0.7435
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7434
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7429
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7427
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7423
Alanine aminotransferase Q9P9M8 Q9P9M8_9EURY Pyrococcus furiosus 2 0.7423
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7418
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7414
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7413
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7412
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7410
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 2 0.7410
Aspartate aminotransferase, mitochondrial P00508 AATM_CHICK Gallus gallus 2 0.7409
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7406
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7405
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7400
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7397
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7397
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7385
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7384
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7383
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7381
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7378
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7374
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7368
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7368
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7364
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7361
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7359
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7356
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7356
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7354
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7349
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.7347
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7347
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7346
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7344
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.7342
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 2 0.7341
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7341
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7340
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7339
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7339
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7338
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7336
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7336
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7335
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7330
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7330
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7330
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7329
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7329
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7328
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7323
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7323
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7322
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7321
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7319
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7318
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7317
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7313
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7313
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7307
Sodium/potassium-transporting ATPase subunit alpha Q4H132 Q4H132_SQUAC Squalus acanthias 2 0.7305
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7302
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7297
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7291
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7290
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7288
Cysteine desulfurase IscS 2 O29689 ISCS2_ARCFU Archaeoglobus fulgidus 2 0.7287
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7285
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 2 0.7284
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7281
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7272
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7267
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7266
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7266
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7261
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7260
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7259
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7258
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7256
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7256
Aspartate aminotransferase P00509 AAT_ECOLI Escherichia coli 2 0.7254
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7249
5-aminolevulinate synthase P18079 HEM1_RHOCB Rhodobacter capsulatus 2 0.7247
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.7244
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7244
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 2 0.7235
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7234
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7230
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7230
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7229
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 2 0.7228
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 2 0.7227
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7226
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7226
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7225
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 2 0.7225
Cysteine desulfurase IscS 2 O29689 ISCS2_ARCFU Archaeoglobus fulgidus 2 0.7222
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7217
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7217
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7210
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7210
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7207
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7207
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.7206
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7203
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7202
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7201
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7198
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7194
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7192
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7190
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase P12995 BIOA_ECOLI Escherichia coli 2 0.7190
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7187
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7183
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7173
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7173
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 2 0.7167
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 2 0.7166
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 2 0.7166
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 2 0.7165
Aspartate aminotransferase, mitochondrial P00508 AATM_CHICK Gallus gallus 2 0.7164
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7160
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 2 0.7152
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 2 0.7152
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 2 0.7150
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7148
Putative FAD-dependent oxygenase EncM Q9KHK2 Q9KHK2_9ACTN Streptomyces maritimus 2 0.7143
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7136
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7131
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7125
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 2 0.7124
12-oxophytodienoate reductase 1 Q9XG54 OPR1_SOLLC Solanum lycopersicum 2 0.7124
Cell division control protein 42 homolog P60953 CDC42_HUMAN Homo sapiens 2 0.7124
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 2 0.7121
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7119
Xanthine dehydrogenase/oxidase P22985 XDH_RAT Rattus norvegicus 2 0.7118
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7118
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7114
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 2 0.7111
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7111
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 2 0.7104
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7103
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7101
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7099
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7098
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7095
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7090
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7088
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase P47229 BPHD_PARXL Paraburkholderia xenovorans 2 0.7084
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7081
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7070
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7066
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 2 0.7063
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7060
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7059
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7059
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 2 0.7052
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7048
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 2 0.7047
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7047
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7039
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7039
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7035
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7035
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7028
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 2 0.7014
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7012
Acetylornithine/succinyldiaminopimelate aminotransferase P40732 ARGD_SALTY Salmonella typhimurium 2 0.7011
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7010
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 2 0.7009
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7007
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7000

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