2-hydroxycanthin-6-one - Compound Card

2-hydroxycanthin-6-one

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2-hydroxycanthin-6-one

Structure
Zoomed Structure
  • Family: Plantae - Simaroubaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Indole Alkaloid
Canonical Smiles c1c(nc2ccc(=O)n3c4ccccc4c1c23)O
InChI InChI=1S/C14H8N2O2/c17-12-7-9-8-3-1-2-4-11(8)16-13(18)6-5-10(15-12)14(9)16/h1-7H,(H,15,17)
InChIKey BDCOKQCMZJCYDY-UHFFFAOYSA-N
Formula C14H8N2O2
HBA 4
HBD 1
MW 236.23
Rotatable Bonds 0
TPSA 54.6
LogP 2.14
Number Rings 4
Number Aromatic Rings 4
Heavy Atom Count 18
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 236.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Quassia amara Simaroubaceae Plantae 43725

Showing of synonyms

  • Njar VC, Alao TO, et al. (1993). 2-Methoxycanthin-6-one: A new alkaloid from the stem wood of Quassia amara. Planta Medica, 1993,59(3), 259-261. [View]
Pubchem: 14082276
Nmrshiftdb2: 70025131

No compound-protein relationship available.

Structure

SMILES: c1cccc(c1c23)n4c2c(ccc4=O)ncc3

Level: 0

Mol. Weight: 236.23 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.87
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.13
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.73

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.48
Plasma Protein Binding
73.91
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
2.21
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.91
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.44
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.1
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Toxic
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.75
Rat (Acute)
2.29
Rat (Chronic Oral)
1.75
Fathead Minnow
4.51
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Toxic
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
459.72
Hydration Free Energy
-12.58
Log(D) at pH=7.4
1.36
Log(P)
1.41
Log S
-4.63
Log(Vapor Pressure)
-7.71
Melting Point
306.06
pKa Acid
7.36
pKa Basic
5.82
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.9770
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9740
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.9628
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9620
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9549
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.9504
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.9446
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.9439
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9431
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 4 0.9389
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.9353
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9341
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9341
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 4 0.9324
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.9289
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9251
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.9221
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9210
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9177
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9149
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.9024
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8932
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.8912
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8911
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8908
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8885
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8859
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8840
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8806
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8794
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8706
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8698
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8692
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8668
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8646
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8644
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 3 0.8622
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8597
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8513
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8506
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8473
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8465
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8443
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8438
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8399
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8380
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8376
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8373
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8372
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8372
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8307
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.8241
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8237
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8193
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8174
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8159
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 3 0.8149
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8134
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8127
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8070
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8063
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8057
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7951
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7950
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7949
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7945
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7935
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7932
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7890
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7885
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.7879
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 4 0.7858
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7855
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.7847
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7842
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7830
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7802
Thymidylate synthase P04818 TYSY_HUMAN Homo sapiens 3 0.7769
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7711
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7710
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7700
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7683
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7673
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7662
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7658
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7656
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7644
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7639
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7632
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7632
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7616
Protoporphyrinogen oxidase, mitochondrial O24164 PPOM_TOBAC Nicotiana tabacum 2 0.7616
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7613
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7611
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7583
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7573
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7564
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7554
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7542
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7529
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7523
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7510
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7503
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7489
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 3 0.7479
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7463
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7463
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7460
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7454
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7452
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7451
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7447
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic Q1XH05 HGL1B_WHEAT Triticum aestivum 3 0.7447
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7434
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7434
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7428
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7422
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7408
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7407
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7403
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7389
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7384
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7373
Elongation factor 1-alpha O59153 EF1A_PYRHO Pyrococcus horikoshii 3 0.7370
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7370
Ribosome biogenesis GTPase YqeH D0VWU7 D0VWU7_GEOSE Geobacillus stearothermophilus 3 0.7367
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7363
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7337
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7335
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7334
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7332
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7330
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7326
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7325
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7320
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7317
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7311
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7302
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7292
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7284
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7284
Beta-1,4-galactosyltransferase 1 P08037 B4GT1_BOVIN Bos taurus 3 0.7282
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7279
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7274
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 ODPA_HUMAN Homo sapiens 3 0.7273
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7263
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7257
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.7252
Elongation factor 1-alpha P02994 EF1A_YEAST Saccharomyces cerevisiae 3 0.7248
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 2 0.7248
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7244
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7217
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 3 0.7214
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7214
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7201
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7188
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7184
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7181
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7178
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7169
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7165
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7163
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7163
Elongation factor Tu 1 P0CE47 EFTU1_ECOLI Escherichia coli 3 0.7162
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7161
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7158
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7153
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7133
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7104
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7098
Kynurenine 3-monooxygenase P38169 KMO_YEAST Saccharomyces cerevisiae 2 0.7095
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7093
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7087
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7084
Activated CDC42 kinase 1 Q07912 ACK1_HUMAN Homo sapiens 4 0.7069
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 2 0.7068
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7063
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 2 0.7060
CalS13 Q8KND8 Q8KND8_MICEC Micromonospora echinospora 3 0.7060
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7058
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7057
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7048
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7043
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7041
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7029
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7022
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7018
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7017

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