(E)-2,3-diacetoxy-7-(3'',4''-dihydroxy-5''-methoxyphenyl)-1-(4'-hydroxy-3'-methoxyphenyl)-5-heptene - Compound Card

(E)-2,3-diacetoxy-7-(3'',4''-dihydroxy-5''-methoxyphenyl)-1-(4'-hydroxy-3'-methoxyphenyl)-5-heptene

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(E)-2,3-diacetoxy-7-(3'',4''-dihydroxy-5''-methoxyphenyl)-1-(4'-hydroxy-3'-methoxyphenyl)-5-heptene

Structure
Zoomed Structure
  • Family: Plantae - Zingiberaceae
  • Kingdom: Plantae
  • Class: Phenolic
    • Subclass: Diarylheptanoid
Canonical Smiles COc1cc(ccc1O)CC(C(OC(=O)C)C/C=C/Cc1cc(O)c(c(c1)OC)O)OC(=O)C
InChI InChI=1S/C25H30O9/c1-15(26)33-21(8-6-5-7-17-11-20(29)25(30)24(14-17)32-4)23(34-16(2)27)13-18-9-10-19(28)22(12-18)31-3/h5-6,9-12,14,21,23,28-30H,7-8,13H2,1-4H3/b6-5+
InChIKey AWLMGIAUTPNIIB-AATRIKPKSA-N
Formula C25H30O9
HBA 9
HBD 3
MW 474.51
Rotatable Bonds 11
TPSA 131.75
LogP 3.42
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 34
Formal Charge 0
Fraction CSP3 0.36
Exact Mass 474.19
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Siphonochilus aethiopicus Zingiberaceae Plantae 199663

Showing of synonyms

  • Igoli NP, Al-Tannak NF, et al. (2020). Antiplasmodial activity of a novel diarylheptanoid from Siphonochilus aethiopicus. Natural Product Research,2020,35(24),5588-5595. [View]

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CC=CCCCCc2ccccc2

Level: 1

Mol. Weight: 474.51 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 474.51 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp)
-5.17
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.690
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.13

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.970
Plasma Protein Binding
19.63
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
12.140
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.190
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.180
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
7.180
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-101.180
Rat (Acute)
1.930
Rat (Chronic Oral)
2.810
Fathead Minnow
5.360
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
490.990
Hydration Free Energy
-3.190
Log(D) at pH=7.4
2.800
Log(P)
2.26
Log S
-4.83
Log(Vapor Pressure)
-9.38
Melting Point
104.9
pKa Acid
9.06
pKa Basic
4.39
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9701
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9494
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.9484
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9400
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9374
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9362
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9302
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9291
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9246
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9238
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9209
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9205
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9117
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9105
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.9098
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9074
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.9031
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9006
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9004
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8955
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8927
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8920
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8900
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8875
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.8862
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8857
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8854
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8844
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8831
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8829
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8825
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8799
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8797
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8795
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8770
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.8763
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8744
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 4 0.8730
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8728
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8725
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.8693
Uracil-DNA glycosylase P20536 UNG_VACCC Vaccinia virus 4 0.8684
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8649
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8646
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8645
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.8627
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8621
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 4 0.8611
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8600
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8588
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 3 0.8574
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8567
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8514
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.8510
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8496
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8484
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.8477
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 3 0.8474
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8447
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8447
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.8431
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8410
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.8381
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8361
Uridine phosphorylase 2 O95045 UPP2_HUMAN Homo sapiens 4 0.8350
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8350
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8292
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 4 0.8276
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8261
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8259
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8239
Uracil-DNA glycosylase P13051 UNG_HUMAN Homo sapiens 4 0.8238
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8238
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8227
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8206
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8175
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8151
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8146
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8139
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 4 0.8132
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8118
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8091
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.8072
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8041
Uracil-DNA glycosylase P9WFQ9 UNG_MYCTU Mycobacterium tuberculosis 4 0.8022
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 3 0.8006
Copper-transporting ATPase Q97UU7 Q97UU7_SACS2 Saccharolobus solfataricus 4 0.7999
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7979
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7974
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7908
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7859
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7854
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7852
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7838
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 4 0.7833
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7832
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7815
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7814
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7802
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7793
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7788
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7778
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7769
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7756
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7740
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7723
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7722
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7713
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7699
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.7690
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7686
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7685
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 4 0.7678
ATP-dependent Clp protease proteolytic subunit P56156 CLPP_HELPY Helicobacter pylori 4 0.7650
S-methyl-5'-thioadenosine phosphorylase Q97W94 MTAP_SACS2 Saccharolobus solfataricus 3 0.7647
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7634
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7621
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7612
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7611
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7599
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 2 0.7597
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7563
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7560
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7553
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7544
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7541
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7527
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7515
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7505
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7504
Bifunctional protein GAL10 P04397 GAL10_YEAST Saccharomyces cerevisiae 4 0.7503
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 3 0.7503
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7502
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7500
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7497
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7494
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7489
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7484
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7477
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7470
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7465
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7464
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 4 0.7445
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7430
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7430
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7426
Ribosomal RNA small subunit methyltransferase E Q5SKI6 Q5SKI6_THET8 Thermus thermophilus 3 0.7420
Bifunctional adenosylcobalamin biosynthesis protein CobU Q05599 COBU_SALTY Salmonella typhimurium 4 0.7407
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7404
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7394
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7391
N-glycosylase/DNA lyase O15527 OGG1_HUMAN Homo sapiens 3 0.7391
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7391
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7389
Bifunctional protein GlmU P43889 GLMU_HAEIN Haemophilus influenzae 3 0.7380
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7361
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7361
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7350
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7349
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7347
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7346
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7345
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 3 0.7343
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7341
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7340
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7332
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7331
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7327
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7326
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7320
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7316
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7316
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7314
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7312
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7311
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase P9WNH5 HSAD_MYCTU Mycobacterium tuberculosis 3 0.7309
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7308
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7306
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7301
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7300
Peptide deformylase Q9I7A8 DEF_PSEAE Pseudomonas aeruginosa 4 0.7291
[LysW]-aminoadipate kinase O50147 LYSZ_THET2 Thermus thermophilus 3 0.7290
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.7284
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7279
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7274
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7271
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7269
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7267
Ribosomal RNA small subunit methyltransferase E Q5SKI6 Q5SKI6_THET8 Thermus thermophilus 3 0.7265
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7259
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7249
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7248
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7243
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7236
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7235
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7233
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7231
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7225
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 3 0.7214
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7211
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7206
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 4 0.7201
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.7200
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7196
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7194
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7192
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7189
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7188
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7186
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 4 0.7182
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7182
Small heat shock protein StHsp14.0 Q970D9 Q970D9_SULTO Sulfurisphaera tokodaii 3 0.7179
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7170
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7169
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 2 0.7169
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7168
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7168
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7165
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7152
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7150
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7149
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7142
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7142
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7129
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7123
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7122
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7120
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7120
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7118
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7117
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 3 0.7114
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7113
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7107
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7107
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7104
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7103
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7092
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7086
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7071
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7071
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7068
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7065
Histone-lysine N-methyltransferase 2C Q8NEZ4 KMT2C_HUMAN Homo sapiens 3 0.7063
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7057
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7054
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7042
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7040
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7040
tRNA (cytidine-2'-O-)-methyltransferase TrmJ Q4JB16 TRMJ_SULAC Sulfolobus acidocaldarius 3 0.7032
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7031
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7029
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7027
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Q8GZB6 SUVH4_ARATH Arabidopsis thaliana 3 0.7026
Orf1ab polyprotein Q6T1E9 Q6T1E9_CVHSA SARS coronavirus CUHK-L2 3 0.7024
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7023
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7023
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Q9NTG7 SIR3_HUMAN Homo sapiens 4 0.7019
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7019
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.7016
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7016
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7014
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7013
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7011
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7008
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 3 0.7006
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7005
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7001

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