1,7-dihydroxyxanthone - Compound Card

1,7-dihydroxyxanthone

Select a section from the left sidebar

1,7-dihydroxyxanthone

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Xanthone
Canonical Smiles Oc1ccc2c(c1)c(=O)c1c(o2)cccc1O
InChI InChI=1S/C13H8O4/c14-7-4-5-10-8(6-7)13(16)12-9(15)2-1-3-11(12)17-10/h1-6,14-15H
InChIKey KDXFPEKLLFWHMN-UHFFFAOYSA-N
Formula C13H8O4
HBA 4
HBD 2
MW 228.2
Rotatable Bonds 0
TPSA 70.67
LogP 2.36
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 17
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 228.04
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Allanblackia floribunda Guttiferae Plantae 469914
2 Allanblackia floribunda Guttiferae Plantae 469914
3 Allanblackia gabonensis Guttiferae Plantae 469913
4 Garcinia nobilis Guttiferae Plantae 469933
5 Harungana madagascariensis Hypericaceae Plantae 198768
6 Hypericum riparium Hypericaceae Plantae 269018
7 Cassia obtusifolia Leguminosae/Fabaceae Plantae 346985

Showing of synonyms

  • Kouam SF, Khan SN, et al. (2006). Alpha-glucosidase inhibitory anthranols, kenganthranols A-C, from the stem bark of Harungana madagascariensis.. Journal of natural products,2006, 69(2), 229-233. [View] [PubMed]
  • Sob S, Wabo H, et al. (2010). Anthraquinones, sterols, triterpenoids and xanthones from Cassia obtusifolia. Biochemical Systematics and Ecology, 2010, 38(3), 342-345. [View]
  • Tala MF, Talontsi FM, et al. (2015). Antimicrobial and cytotoxic constituents from native Cameroonian medicinal plant Hypericum riparium.. Fitoterapia,2015, 102, 149-155. [View] [PubMed]
  • Kuete V, Azebaze AG, et al. (2011). Antioxidant, antitumor and antimicrobial activities of the crude extract and compounds of the root bark of Allanblackia floribunda.. Pharmaceutical biology,2011, 49(1), 57-65. [View] [PubMed]
  • Azebaze AG, Teinkela JE, et al. (2015). Antiplasmodial activity of some phenolic compounds from Cameroonians Allanblackia.. African health sciences,2015, 15(3), 835-840. [View] [PubMed]
  • Fouotsa H, Dzoyem JP, et al. (2021). Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl.. Natural product research,2021, 35(24), 5604-5611. [View] [PubMed]
  • Menasria F, Azebaze AG, et al. (2008). Apoptotic effects on B-cell chronic lymphocytic leukemia (B-CLL) cells of heterocyclic compounds isolated from Guttiferaes.. Leukemia research,2008, 32(12), 1914-1926. [View] [PubMed]
Pubchem: 5281631
Kegg Ligand: C10061
Chebi: 4946
Nmrshiftdb2: 60021426
Metabolights: MTBLC4946
Bindingdb: 50268290
CPRiL: 85335
Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 228.2 g/mol

Anti-plasmodial
Antimicrobial
Antioxidant
Antitumor

Absorption

Caco-2 (logPapp)
-4.94
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.560
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.63

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.780
Plasma Protein Binding
72.75
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.640
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.120
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.070
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.820
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.560
Rat (Acute)
1.990
Rat (Chronic Oral)
2.590
Fathead Minnow
4.500
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
411.440
Hydration Free Energy
-11.920
Log(D) at pH=7.4
3.290
Log(P)
3.28
Log S
-3.81
Log(Vapor Pressure)
-8.44
Melting Point
245.12
pKa Acid
5.89
pKa Basic
7.84
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.9573
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9291
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9230
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.9188
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9186
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9171
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.9033
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.9004
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8970
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8876
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8865
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8864
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8841
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8817
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8770
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8744
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8739
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8728
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8719
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8655
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8645
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8619
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8618
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8617
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8616
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8591
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.8579
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8567
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8563
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8541
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8497
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8494
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8476
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8442
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.8434
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8417
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.8409
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8387
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8336
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8332
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8311
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8309
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8307
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.8284
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8272
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 3 0.8269
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8238
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.8186
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8157
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8123
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.8083
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8061
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8060
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8053
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8012
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7981
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7977
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7962
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7956
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7944
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7937
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7929
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7915
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7914
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7905
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7892
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7879
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7877
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7856
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7855
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7842
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7837
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7807
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7785
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7774
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7765
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7746
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7739
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7726
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7713
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7713
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7710
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7707
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7698
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7696
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7687
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7684
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7675
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7662
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7649
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7635
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7606
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7599
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7578
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7573
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7571
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7568
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7558
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7558
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7552
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7544
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7537
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7516
Bifunctional dihydrofolate reductase-thymidylate synthase D9N170 D9N170_PLAFA Plasmodium falciparum 3 0.7512
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7510
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7509
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7500
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7492
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7492
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7485
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7481
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7480
Tubulin alpha chain A0A0R4I993 A0A0R4I993_SUSBA Sus barbatus 3 0.7478
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7465
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7463
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7458
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7449
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7445
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7444
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7441
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7435
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7435
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7431
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7420
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7416
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7412
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7408
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7406
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7398
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7398
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7390
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7383
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7383
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7381
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7377
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7377
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7377
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7374
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7374
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7370
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7366
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7366
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7363
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.7359
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7352
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7347
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7339
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7318
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7308
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7305
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7302
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7297
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7294
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7284
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7284
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7283
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7278
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7267
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7260
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7257
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7252
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7251
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7244
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7243
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7238
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7238
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7218
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7217
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7213
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7212
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7210
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7204
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7201
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7199
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 3 0.7196
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7179
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7178
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.7176
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7174
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7158
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7157
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7144
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7132
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7123
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7112
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7105
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7098
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7091
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7083
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 3 0.7078
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7073
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7071
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7063
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7059
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7055
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7055
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7049
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7047
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7047
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7045
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7043
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7039
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7034
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7033
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.7032
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7030
Activated CDC42 kinase 1 Q07912 ACK1_HUMAN Homo sapiens 3 0.7028
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7006
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7002
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7002
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7001

Download SDF