1,5-dihydroxyxanthone - Compound Card

1,5-dihydroxyxanthone

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1,5-dihydroxyxanthone

Structure
Zoomed Structure
  • Family: Plantae - Hypericaceae
  • Kingdom: Plantae
  • Class: Xanthone
Canonical Smiles Oc1cccc2c1oc1cccc(c1c2=O)O
InChI InChI=1S/C13H8O4/c14-8-4-2-6-10-11(8)12(16)7-3-1-5-9(15)13(7)17-10/h1-6,14-15H
InChIKey APIPFXZYOMIJQG-UHFFFAOYSA-N
Formula C13H8O4
HBA 4
HBD 2
MW 228.2
Rotatable Bonds 0
TPSA 70.67
LogP 2.36
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 17
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 228.04
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Allanblackia floribunda Guttiferae Plantae 469914
2 Garcinia polyantha Guttiferae Plantae 469941
3 Garcinia polyantha Guttiferae Plantae 469941
4 Hypericum roeperianum Hypericaceae Plantae —

Showing of synonyms

  • Lannang AM, Sema DK, et al. (2018). A new depsidone derivative from the leaves of Garcinia polyantha.. Natural product research,2018, 32(9), 1033-1038. [View] [PubMed]
  • Nkengfack AE, Azebaze GA, et al. (2002). A prenylated xanthone from Allanblackia floribunda.. Phytochemistry,2002, 60(4), 381-384. [View] [PubMed]
  • Demgne OMF, Damen F, et al. (2021). Botanicals and phytochemicals from the bark of Hypericum roeperianum (Hypericaceae) had strong antibacterial activity and showed synergistic effects with antibiotics against multidrug-resistant bacteria expressing active efflux pumps.. Journal of ethnopharmacology,2021, 277, 114257. [View] [PubMed]
  • Louh GN, Lannang AM, et al. (2008). Polyanxanthone A, B and C, three xanthones from the wood trunk of Garcinia polyantha Oliv.. Phytochemistry,2008, 69(4), 1013-1017. [View] [PubMed]
Pubchem: 5480299
Nmrshiftdb2: 60077481
Bindingdb: 50155419

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 228.2 g/mol

Anticholinesterase

Absorption

Caco-2 (logPapp)
-4.82
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.500
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.76

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.810
Plasma Protein Binding
74.96
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.800
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.020
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.160
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.770
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.450
Rat (Acute)
1.990
Rat (Chronic Oral)
2.660
Fathead Minnow
4.520
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
402.570
Hydration Free Energy
-10.990
Log(D) at pH=7.4
3.470
Log(P)
3.26
Log S
-4.2
Log(Vapor Pressure)
-8.11
Melting Point
225.04
pKa Acid
4.84
pKa Basic
7.43
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.9668
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9335
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9308
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9274
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8868
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8858
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8848
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8842
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8827
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8801
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8768
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8751
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8748
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8706
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8703
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8657
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8644
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.8612
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8612
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8590
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8587
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8528
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.8491
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8487
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8412
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8359
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8357
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8351
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8342
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8312
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8292
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8274
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8253
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8245
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8176
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.8125
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8107
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.8089
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.8079
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8068
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8068
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8059
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8055
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.8050
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8034
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.8022
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8020
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8009
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.8006
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8003
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7995
Cobalt-precorrin-4 C(11)-methyltransferase O87696 CBIF_BACME Priestia megaterium 3 0.7951
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.7948
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7921
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7914
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7913
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7897
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7873
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7871
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7866
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7862
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7852
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7824
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7822
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7815
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7806
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7796
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7757
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7748
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7734
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7677
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7667
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7646
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7626
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7622
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7611
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7607
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 3 0.7606
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7600
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7567
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7562
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7554
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7544
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7533
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7528
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7526
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7508
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7500
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7492
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7486
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7483
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7478
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7473
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7467
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7467
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7463
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7437
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7430
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7429
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7418
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7417
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.7413
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7408
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7401
Thiosulfate reductase Q72LA4 Q72LA4_THET2 Thermus thermophilus 4 0.7399
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7394
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7360
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7323
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7312
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7312
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7297
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7297
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7296
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7288
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7285
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7285
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.7284
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7273
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7273
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7269
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7264
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7260
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7248
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7241
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7239
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7233
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.7229
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7225
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7224
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7221
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7213
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7213
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7211
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.7204
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7191
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7191
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7189
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7186
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7183
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7180
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7174
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7158
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7154
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7144
Nicotinamide riboside kinase 1 Q9NWW6 NRK1_HUMAN Homo sapiens 3 0.7143
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7139
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7134
Dimethylglycine dehydrogenase, mitochondrial Q63342 M2GD_RAT Rattus norvegicus 4 0.7126
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7120
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7119
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7118
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7110
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7100
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7099
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7092
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.7088
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7086
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7086
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7085
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7080
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7073
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7072
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7070
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7069
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7067
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7065
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7063
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7055
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7054
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.7052
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7052
Activated CDC42 kinase 1 Q07912 ACK1_HUMAN Homo sapiens 3 0.7046
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7031
Bifunctional dihydrofolate reductase-thymidylate synthase D9N170 D9N170_PLAFA Plasmodium falciparum 3 0.7022
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7007
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 2 0.7003
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7000

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